Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | APP | P05067 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10751127 | 0.78 | METAP2 (0.50) | CYP1A2KDM4EMEN1KMT2ALMNA | |
| SCHEMBL426522 | 0.78 | KMT2A (0.66) | KDM4EMEN1MAPTKMT2ALMNA | |
| SCHEMBL8690909 | 0.77 | MAOA (0.50) | LMNAHTTALDH1A1HPGDGAA | |
| SCHEMBL10836345 | 0.75 | CYP1A2 (0.53) | CYP1A2KDM4EMEN1KMT2ALMNA | |
| SCHEMBL15636237 | 0.75 | MAPT (0.73) | KDM4EMEN1MAPTKMT2ALMNA | |
| SCHEMBL10753961 | 0.74 | METAP2 (0.47) | CYP1A2KDM4EMEN1KMT2ALMNA | |
| SCHEMBL27581971 | 0.74 | CYP1A2 (0.58) | CYP1A2LMNATDP1HTTALDH1A1 | |
| SCHEMBL5554912 | 0.73 | RPS6KB1 (0.65) | CYP1A2KDM4EMAPTLMNAHTT | |
| SCHEMBL31204891 | 0.73 | RPS6KB1 (0.65) | CYP1A2KDM4EMAPTLMNAHTT | |
| SCHEMBL8692447 | 0.72 | KDM4E (0.68) | KDM4EMEN1MAPTKMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932270-B2 | Certain chemical entities, compositions, and methods | CYTOKINETICS, INC. (US) | 2011-04-26 | — | — | US | disclosed |