Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2RL1 | P55085 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | CNR1 | P21554 | 3/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8084703 | 0.88 | CNR1 (0.50) | ALDH1A1CNR1KMT2AMAPK1L3MBTL1 | |
| SCHEMBL4205589 | 0.87 | CNR1 (0.52) | ALDH1A1CNR1MAPK1L3MBTL1 | |
| SCHEMBL4220980 | 0.87 | CNR1 (0.52) | ALDH1A1CNR1MAPK1L3MBTL1 | |
| SCHEMBL4214273 | 0.87 | CNR1 (0.52) | ALDH1A1CNR1MAPK1L3MBTL1 | |
| SCHEMBL28348314 | 0.87 | CNR1 (0.52) | ALDH1A1CNR1MAPK1L3MBTL1 | |
| SCHEMBL4214279 | 0.87 | CNR1 (0.52) | ALDH1A1CNR1MAPK1L3MBTL1 | |
| SCHEMBL4210164 | 0.87 | CNR1 (0.52) | ALDH1A1CNR1MAPK1L3MBTL1 | |
| SCHEMBL4214982 | 0.87 | CNR1 (0.52) | ALDH1A1CNR1MAPK1L3MBTL1 | |
| SCHEMBL7500299 | 0.84 | ALDH1A1 (0.50) | ALDH1A1HDAC3HDAC1HDAC2KMT2A | |
| SCHEMBL16324874 | 0.84 | ALDH1A1 (0.57) | F2RL1ALDH1A1KMT2AMAPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150175556-A1 | DIHYDROPYRIMIDIN-2(1H)-ONES AND DIHYDROPYRIMIDIN-2(1H)-THIONES AS INHIBITORS OF SODIUM IODIDE SYMPORTER | COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES (FR) | 2015-06-25 | — | — | US | disclosed |
| EP-2867213-A1 | DIHYDROPYRIMIDIN-2(1H)-ONES AND DIHYDROPYRIMIDIN-2(1H)-THIONES AS INHIBITORS OF SODIUM IODIDE SYMPORTER | Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR) | 2015-05-06 | — | — | EP | disclosed |
| WO-2014203044-A1 | DIHYDROPYRIMIDIN-2(1H)-ONES AND DIHYDROPYRIMIDIN-2(1H)-THIONES AS INHIBITORS OF SODIUM IODIDE SYMPORTER | COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES (FR) | 2014-12-24 | — | — | WO | disclosed |
| EP-2682389-A1 | Dihydropyrimidin-2(1H)-ones and dihydropyrimidin-2(1H)-thiones as inhibitors of sodium iodide symporter | COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES (FR) | 2014-01-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150175556-A1 | DIHYDROPYRIMIDIN-2(1H)-ONES AND DIHYDROPYRIMIDIN-2(1H)-THIONES AS INHIBITORS OF SODIUM IODIDE SYMPORTER | SLC40A1, SLC5A11, SLC20A1 | F2RL1 2193/4885ALDH1A1 583/4885CNR1 1248/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.