Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 8/20 | 0.44 |
| ▸ | DRD1 | P21728 | 8/20 | 0.44 |
| ▸ | DRD5 | P21918 | 8/20 | 0.44 |
| ▸ | DRD3 | P35462 | 7/20 | 0.44 |
| ▸ | DRD4 | P21917 | 6/20 | 0.44 |
| ▸ | MAOA | P21397 | 2/20 | 0.44 |
| ▸ | MAOB | P27338 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.41 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.40 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Orotic Acid SCHEMBL162921 | 0.84 | ALDH1A1 (0.53) | ALDH1A1LMNATSHRDRD2DRD3 | |
| Orotic Acid SCHEMBL175081 | 0.83 | ALDH1A1 (0.62) | ALDH1A1LMNATSHRDRD2DRD1 | |
| Orotic Acid SCHEMBL29394966 | 0.76 | ALDH1A1 (1.00) | ALDH1A1LMNATSHRKDM4ESMN1; SMN2 | |
| Orotic Acid SCHEMBL431534 | 0.76 | ALDH1A1 (1.00) | ALDH1A1LMNATSHRKDM4ESMN1; SMN2 | |
| Orotic Acid SCHEMBL20865 | 0.76 | ALDH1A1 (1.00) | ALDH1A1LMNATSHRKDM4ESMN1; SMN2 | |
| Orotic Acid SCHEMBL18894201 | 0.75 | ALDH1A1 (0.88) | ALDH1A1LMNATSHRKDM4ESMN1; SMN2 | |
| Orotic Acid SCHEMBL23859825 | 0.75 | ALDH1A1 (0.95) | ALDH1A1LMNATSHRKDM4ESMN1; SMN2 | |
| Orotic Acid SCHEMBL422602 | 0.75 | ALDH1A1 (0.95) | ALDH1A1LMNATSHRKDM4ESMN1; SMN2 | |
| Orotic Acid SCHEMBL1005001 | 0.75 | ALDH1A1 (0.95) | ALDH1A1LMNATSHRKDM4ESMN1; SMN2 | |
| Orotic Acid SCHEMBL16194628 | 0.75 | ALDH1A1 (0.95) | ALDH1A1LMNATSHRKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611449-A1 | ADMINISTRATION OF LORCASERIN TO INDIVIDUALS WITH RENAL IMPAIRMENT | Arena Pharmaceuticals, Inc. (US) | 2013-07-10 | — | — | EP | disclosed |
| EP-2611427-A2 | MODIFIED-RELEASE DOSAGE FORMS OF 5-HT2C AGONISTS USEFUL FOR WEIGHT MANAGEMENT& xA; | Arena Pharmaceuticals, Inc. (US) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012030927-A2 | MODIFIED-RELEASE DOSAGE FORMS OF 5-HT2C AGONISTS USEFUL FOR WEIGHT MANAGEMENT | ARENA PHARMACEUTICALS, INC. (US) | 2012-03-08 | — | — | WO | disclosed |
| WO-2012030939-A1 | ADMINISTRATION OF LORCASERIN TO INDIVIDUALS WITH RENAL IMPAIRMENT | ARENA PHARMACEUTICALS, INC. (US) | 2012-03-08 | — | — | WO | disclosed |