Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | HTR2C | P28335 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.42 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | AHR | P35869 | 1/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Orotic Acid SCHEMBL163210 | 0.83 | ALDH1A1 (0.58) | ALDH1A1LMNATSHRCYP2C19GPR84 | |
| Orotic Acid SCHEMBL174876 | 0.83 | HTR2C (0.59) | ALDH1A1LMNAHTR2CTSHRHTR2B | |
| Orotic Acid SCHEMBL162920 | 0.83 | ALDH1A1 (0.45) | ALDH1A1LMNAHTR2CTSHRGPR84 | |
| Orotic Acid SCHEMBL165966 | 0.82 | ALDH1A1 (0.50) | ALDH1A1LMNAHTR2CTSHRCYP2C19 | |
| Orotic Acid SCHEMBL5651941 | 0.80 | ALDH1A1 (0.95) | ALDH1A1LMNATSHRCYP2C19GPR84 | |
| Orotic Acid SCHEMBL672212 | 0.80 | ALDH1A1 (0.72) | ALDH1A1LMNATSHRCYP2C19GPR84 | |
| Orotic Acid SCHEMBL162921 | 0.79 | ALDH1A1 (0.53) | ALDH1A1LMNATSHRCYP2C19GPR84 | |
| Orotic Acid SCHEMBL29394966 | 0.79 | ALDH1A1 (1.00) | ALDH1A1LMNATSHRCYP2C19GPR84 | |
| Orotic Acid SCHEMBL431534 | 0.79 | ALDH1A1 (1.00) | ALDH1A1LMNATSHRCYP2C19GPR84 | |
| Orotic Acid SCHEMBL20865 | 0.79 | ALDH1A1 (1.00) | ALDH1A1LMNATSHRCYP2C19GPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012030953-A1 | 5-HT2C RECEPTOR AGONISTS IN THE TREATMENT OF DISORDERS AMELIORATED BY REDUCTION OF NOREPINEPHRINE LEVEL | ARENA PHARMACEUTICALS, INC. (US) | 2012-03-08 | — | — | WO | disclosed |