Orotic Acid

Orotic Acid

SCHEMBL20865

O=C(O)c1cc(=O)[nH]c(=O)[nH]1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 1.00
LMNA P02545 1/20 1.00
CYP2C19 P33261 2/20 0.63
CYP1A2 P05177 2/20 0.59
ALOX15 P16050 1/20 0.56
NFKB1 P19838 1/20 0.56
BLM P54132 1/20 0.56
SMN1; SMN2 Q16637 1/20 0.56
TSHR P16473 2/20 0.48
GPR84 Q9NQS5 4/20 0.46
GPR35 Q9HC97 3/20 0.46
MEN1 O00255 2/20 0.46
KMT2A Q03164 2/20 0.46
KDM4E B2RXH2 2/20 0.46
HPGD P15428 2/20 0.46
HSD17B10 Q99714 2/20 0.46
GRIN2D O15399 1/20 0.46
GRIN3B O60391 1/20 0.46
GLA P06280 1/20 0.46
GAA P10253 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Orotic Acid SCHEMBL431534 1.00 ALDH1A1 (1.00) ALDH1A1LMNACYP2C19CYP1A2ALOX15
Orotic Acid SCHEMBL29394966 1.00 ALDH1A1 (1.00) ALDH1A1LMNACYP2C19CYP1A2ALOX15
Orotic Acid SCHEMBL422602 0.98 ALDH1A1 (0.95) ALDH1A1LMNACYP2C19CYP1A2ALOX15
Orotic Acid SCHEMBL896844 0.98 ALDH1A1 (0.95) ALDH1A1LMNACYP2C19CYP1A2ALOX15
Orotic Acid SCHEMBL7328854 0.98 ALDH1A1 (0.95) ALDH1A1LMNACYP2C19CYP1A2ALOX15
Orotic Acid SCHEMBL23859825 0.98 ALDH1A1 (0.95) ALDH1A1LMNACYP2C19CYP1A2ALOX15
Orotic Acid SCHEMBL16194628 0.98 ALDH1A1 (0.95) ALDH1A1LMNACYP2C19CYP1A2ALOX15
Orotic Acid SCHEMBL231368 0.98 ALDH1A1 (0.95) ALDH1A1LMNACYP2C19CYP1A2ALOX15
Orotic Acid SCHEMBL1005001 0.98 ALDH1A1 (0.95) ALDH1A1LMNACYP2C19CYP1A2ALOX15
Orotic Acid SCHEMBL122311 0.98 ALDH1A1 (0.95) ALDH1A1LMNACYP2C19CYP1A2ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 32634 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260146271-A1 UDP-SUGAR BIOPRODUCTION USING MICROORGANISM HOSTS Debut Biotechnology, Inc. (US) 2026-05-28 US claimed
EP-4747627-A1 METHODS AND SYSTEMS FOR PREDICTIVE CLASSIFICATION BY MASS SPECTROMETRY AND TRAINED LARGE SPECTRAL MODELS Matterworks Inc (US) 2026-05-27 EP claimed
WO-2026103747-A1 SALT OF THIAZOLE DERIVATIVE INHIBITOR, CRYSTAL FORM THEREOF, PREPARATION METHOD THEREFOR AND USE THEREOF 江苏豪森药业集团有限公司 2026-05-21 WO claimed
US-20260137676-A1 PIPERAZINE SUBSTITUTED PHENOL DERIVATIVE AND USE THEREOF CHENGDU MFS PHARMA. CO., LTD. (CN) 2026-05-21 US claimed
EP-4745135-A1 COMPOUND BASED ON THIO-GLUTARIMIDO ISOINDOLINONE SKELETON AND USE THEREOF Gluetacs Therapeutics (Shanghai) Co., Ltd. (CN) 2026-05-20 EP claimed
EP-4745137-A1 GLUTARIMIDE ISOINDOLINONE SKELETON-BASED COMPOUND Gluetacs Therapeutics (Shanghai) Co., Ltd. (CN) 2026-05-20 EP claimed
CN-122070278-A Bifunctional protein degradation agent containing aryl substituted heteroaryl and application thereof 标新生物医药科技(上海)有限公司 2026-05-19 CN claimed
CN-122056884-A Methods of treating pancreatic cancer 坎莫森特里克斯公司 2026-05-19 CN claimed
CN-122070275-A Heterocyclic compound and application thereof 成都麻沸散医药科技有限公司 2026-05-19 CN claimed
CN-122055357-A Heterocyclic compound and application thereof 成都麻沸散医药科技有限公司 2026-05-15 CN claimed
EP-0052341-A1 Orotic acid derivatives and their use as agricultural chemicals UBE INDUSTRIES, LTD. (JP) 1982-05-26 EP claimed
EP-0051278-A1 Soft tertiary amine esters of bio-affecting carboxylic acids, processes for preparing and a pharmaceutical composition containing the same MERCK & CO. INC. (US) 1982-05-12 EP claimed
US-4242363-A OROTIC ACID INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (FR) 1980-12-30 US claimed
US-4186266-A Process for producing 5-fluorouracil ASAHI GLASS COMPANY LIMITED (JP) 1980-01-29 US claimed
US-4123534-A VIGILANCE INCREASING AGENTS Wulfing, Johann W. (DE) 1978-10-31 US claimed
US-4064126-A Process for the production of orotic acid LONZA, LTD. (CH) 1977-12-20 US claimed
US-4061741-A OROTIC ACID OR SALTS FIRMA SERVOMED ARZEI GMBH & CO. PHARMA KG (DT) 1977-12-06 US claimed
US-4045556-A ANTIDEPRESSANTS, PYSCHOSTIMULANTS; SILYLATION SCHWERTNER EBERHARD 1977-08-30 US claimed
US-4000276-A HUMAN SKIN KANEBO, LTD. (JA) 1976-12-28 US claimed
US-3944550-A Vitamin E orotate and a method of producing the same KANEBO LTD. (JA) 1976-03-16 US claimed