Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 10/20 | 0.42 |
| ▸ | CA2 | P00918 | 10/20 | 0.42 |
| ▸ | CA9 | Q16790 | 10/20 | 0.42 |
| ▸ | CA12 | O43570 | 9/20 | 0.42 |
| ▸ | JAK2 | O60674 | 2/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.40 |
| ▸ | CA4 | P22748 | 9/20 | 0.40 |
| ▸ | CA7 | P43166 | 8/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.40 |
| ▸ | IKBKB | O14920 | 2/20 | 0.39 |
| ▸ | CHUK | O15111 | 2/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | STK4 | Q13043 | 1/20 | 0.39 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 3/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.38 |
| ▸ | CDK4 | P11802 | 2/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.38 |
| ▸ | CCND1 | P24385 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1632747 | 0.91 | CA1 (0.41) | CA1CA2CA9JAK2CA4 | |
| SCHEMBL1632843 | 0.89 | IKBKB (0.42) | CA1CA2CA9CA12JAK2 | |
| SCHEMBL1633022 | 0.86 | MAPK10 (0.44) | CA1CA2CA9CA12JAK2 | |
| SCHEMBL1631392 | 0.85 | JAK2 (0.55) | CA1CA2CA9CA12JAK2 | |
| SCHEMBL1633358 | 0.81 | IKBKB (0.42) | CA1CA2CA9CA12JAK2 | |
| SCHEMBL1634294 | 0.79 | CA2 (0.44) | CA1CA2CA9CA12PTK2 | |
| SCHEMBL1633189 | 0.77 | SMG1 (0.50) | CA1CA2CA9CA12JAK2 | |
| SCHEMBL1632659 | 0.77 | CA1 (0.47) | CA1CA2CA9CA12JAK2 | |
| SCHEMBL1632394 | 0.75 | SMG1 (0.55) | CA1CA2CA9CA12JAK2 | |
| SCHEMBL1632364 | 0.75 | FGFR4 (0.48) | CA1CA2CA9JAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-20100048561-A1 | QUINAZOLINES FOR PDK1 INHIBITION | NOVARTIS VACCINES & DIAGNOSTICS, INC. (US) | 2010-02-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048561-A1 | QUINAZOLINES FOR PDK1 INHIBITION | PDK1, PDK2, PDK3 | CA1 4702/4885CA2 3577/4885CA9 4102/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.