Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PROKR1 | Q8TCW9 | 18/20 | 1.00 |
| ▸ | FPR2 | P25090 | 9/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16324117 | 0.87 | PROKR1 (1.00) | PROKR1FPR2 | |
| SCHEMBL16323992 | 0.81 | PROKR1 (1.00) | PROKR1FPR2 | |
| SCHEMBL16324361 | 0.80 | PROKR1 (1.00) | PROKR1FPR2LMNA | |
| SCHEMBL15548760 | 0.78 | PROKR1 (1.00) | PROKR1FPR2LMNAKMT2AMAPT | |
| SCHEMBL16323565 | 0.74 | PROKR1 (1.00) | PROKR1FPR2 | |
| SCHEMBL15549371 | 0.70 | FPR2 (1.00) | PROKR1FPR2LMNAKMT2A | |
| SCHEMBL15549259 | 0.70 | PROKR1 (1.00) | PROKR1FPR2LMNAKMT2A | |
| SCHEMBL15548037 | 0.70 | FPR2 (1.00) | PROKR1FPR2LMNAKMT2A | |
| SCHEMBL15548422 | 0.70 | ALDH1A1 (0.57) | PROKR1FPR2 | |
| SCHEMBL15548339 | 0.70 | FPR2 (1.00) | PROKR1FPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10335402-B2 | Sulfonyl piperidine derivatives and their use for treating prokineticin mediated gastrointestinal disorders | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2019-07-02 | — | — | US | claimed |
| US-10308635-B2 | 1-sulfonyl piperidine derivatives as modulators of prokineticin receptors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2019-06-04 | — | — | US | claimed |
| US-10208016-B2 | 1-sulfonyl piperidine derivatives as modulators of prokineticin receptors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2019-02-19 | — | — | US | claimed |
| US-20180251445-A1 | 1-SULFONYL PIPERIDINE DERIVATIVES AS MODULATORS OF PROKINETICIN RECEPTORS | TAKEDA PHARMACEUTICALS CO (JP) | 2018-09-06 | — | — | US | claimed |
| EP-3010900-B1 | 1-SULFONYL PIPERIDINE DERIVATIVES AS MODULATORS OF PROKINETICIN RECEPTORS | TAKEDA PHARMACEUTICALS CO (JP) | 2018-01-03 | — | — | EP | claimed |
| US-20170340621-A1 | SULFONYL PIPERIDINE DERIVATIVES AND THEIR USE FOR TREATING PROKINETICIN MEDIATED GASTROINTESTINAL DISORDERS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2017-11-30 | — | — | US | claimed |
| EP-3218363-A1 | SULFONYL PIPERIDINE DERIVATIVES AND THEIR USE FOR TREATING PROKINETICIN MEDIATED GASTROINTESTINAL DISORDERS | Takeda Pharmaceutical Company Limited (JP) | 2017-09-20 | — | — | EP | claimed |
| WO-2016075457-A1 | SULFONYL PIPERIDINE DERIVATIVES AND THEIR USE FOR TREATING PROKINETICIN MEDIATED GASTROINTESTINAL DISORDERS | TAKEDA CAMBRIDGE LIMITED (GB) | 2016-05-19 | — | — | WO | claimed |
| US-20160122317-A1 | 1-SULFONYL PIPERIDINE DERIVATIVES AS MODULATORS OF PROKINETICIN RECEPTORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-05-05 | — | — | US | claimed |
| EP-3010900-A1 | 1-SULFONYL PIPERIDINE DERIVATIVES AS MODULATORS OF PROKINETICIN RECEPTORS | Takeda Pharmaceutical Company Limited (JP) | 2016-04-27 | — | — | EP | claimed |
| WO-2014202999-A1 | 1-SULFONYL PIPERIDINE DERIVATIVES AS MODULATORS OF PROKINETICIN RECEPTORS | TAKEDA CAMBRIDGE LIMITED (GB) | 2014-12-24 | — | — | WO | claimed |
| US-10335402-B2 | Sulfonyl piperidine derivatives and their use for treating prokineticin mediated gastrointestinal disorders | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2019-07-02 | — | — | US | disclosed |
| US-10335402-B2 | Sulfonyl piperidine derivatives and their use for treating prokineticin mediated gastrointestinal disorders | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2019-07-02 | — | — | US | disclosed |
| US-10308635-B2 | 1-sulfonyl piperidine derivatives as modulators of prokineticin receptors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2019-06-04 | — | — | US | disclosed |
| US-10308635-B2 | 1-sulfonyl piperidine derivatives as modulators of prokineticin receptors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2019-06-04 | — | — | US | disclosed |
| US-20160122317-A1 | 1-SULFONYL PIPERIDINE DERIVATIVES AS MODULATORS OF PROKINETICIN RECEPTORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-05-05 | — | — | US | disclosed |
| US-20160122317-A1 | 1-SULFONYL PIPERIDINE DERIVATIVES AS MODULATORS OF PROKINETICIN RECEPTORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-05-05 | — | — | US | disclosed |
| EP-3010900-A1 | 1-SULFONYL PIPERIDINE DERIVATIVES AS MODULATORS OF PROKINETICIN RECEPTORS | Takeda Pharmaceutical Company Limited (JP) | 2016-04-27 | — | — | EP | disclosed |
| WO-2014202999-A1 | 1-SULFONYL PIPERIDINE DERIVATIVES AS MODULATORS OF PROKINETICIN RECEPTORS | TAKEDA CAMBRIDGE LIMITED (GB) | 2014-12-24 | — | — | WO | disclosed |
| WO-2014202999-A1 | 1-SULFONYL PIPERIDINE DERIVATIVES AS MODULATORS OF PROKINETICIN RECEPTORS | TAKEDA CAMBRIDGE LIMITED (GB) | 2014-12-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180251445-A1 | 1-SULFONYL PIPERIDINE DERIVATIVES AS MODULATORS OF PROKINETICIN RECEPTORS | GIPR, PROKR1, PROKR2 | PROKR1 2/4885FPR2 946/4885LMNA 1031/4885 |
| US-20160122317-A1 | 1-SULFONYL PIPERIDINE DERIVATIVES AS MODULATORS OF PROKINETICIN RECEPTORS | GIPR, PROKR1, PROKR2 | PROKR1 2/4885FPR2 946/4885LMNA 1031/4885 |
| US-10308635-B2 | 1-sulfonyl piperidine derivatives as modulators of prokineticin receptors | GIPR, PROKR1, PROKR2 | PROKR1 2/4885FPR2 946/4885LMNA 1031/4885 |
| US-10335402-B2 | Sulfonyl piperidine derivatives and their use for treating prokineticin mediated gastrointestinal disorders | PROKR1, PROKR2, GIPR | PROKR1 1/4885FPR2 520/4885LMNA 1539/4885 |
| US-20170340621-A1 | SULFONYL PIPERIDINE DERIVATIVES AND THEIR USE FOR TREATING PROKINETICIN MEDIATED GASTROINTESTINAL DISORDERS | PROKR1, PROKR2, GIPR | PROKR1 1/4885FPR2 520/4885LMNA 1539/4885 |
| US-10208016-B2 | 1-sulfonyl piperidine derivatives as modulators of prokineticin receptors | GIPR, PROKR1, PROKR2 | PROKR1 2/4885FPR2 946/4885LMNA 1031/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.