Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 1/20 | 0.52 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.52 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.48 |
| ▸ | PRKDC | P78527 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 2/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.45 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.45 |
| ▸ | MTOR | P42345 | 1/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.45 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.43 |
| ▸ | BRAF | P15056 | 2/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16331614 | 0.91 | GABRG2 (0.49) | GABRG2GABRB3GABRA5PIK3CAPRKDC | |
| SCHEMBL16332832 | 0.90 | PIK3CA (0.48) | GABRG2GABRB3GABRA5PIK3CAPRKDC | |
| SCHEMBL16331561 | 0.86 | BRAF (0.56) | GABRG2GABRB3GABRA5PIK3CAPRKDC | |
| SCHEMBL16332572 | 0.85 | PIK3CA (0.48) | PIK3CAPRKDCPIK3CDPIK3CBMTOR | |
| SCHEMBL16331626 | 0.83 | GABRG2 (0.52) | GABRG2GABRB3GABRA5PIK3CAPRKDC | |
| SCHEMBL16331924 | 0.82 | KDM1A (0.45) | GABRG2GABRB3GABRA5PIK3CAMAP3K5 | |
| SCHEMBL16332328 | 0.82 | MEN1 (0.51) | PIK3CAPRKDCNPC1ABCG2ABCB1 | |
| SCHEMBL16332291 | 0.81 | FLT3 (0.45) | GABRG2GABRB3GABRA5PIK3CAPRKDC | |
| SCHEMBL16331980 | 0.81 | PIK3CA (0.46) | GABRG2GABRB3GABRA5PIK3CAPRKDC | |
| SCHEMBL16331252 | 0.81 | JAK3 (0.46) | NPC1FLT3RAB9ASMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2818472-A1 | Imidazo[4,5-c]pyridine and pyrrolo[3,2-c]pyridine compounds as G-protein-coupled receptor kinase 5 (GRK5) modulators | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2014-12-31 | — | — | EP | claimed |
| EP-2818472-A1 | Imidazo[4,5-c]pyridine and pyrrolo[3,2-c]pyridine compounds as G-protein-coupled receptor kinase 5 (GRK5) modulators | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2014-12-31 | — | — | EP | disclosed |