Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 1/20 | 0.46 |
| ▸ | MTOR | P42345 | 1/20 | 0.46 |
| ▸ | PRKDC | P78527 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | JAK3 | P52333 | 4/20 | 0.46 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
| ▸ | TYK2 | P29597 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
| ▸ | DDX3X | O00571 | 1/20 | 0.44 |
| ▸ | BRAF | P15056 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16332326 | 0.92 | GABRG2 (0.52) | PIK3CAMTORPRKDCEGFRJAK3 | |
| SCHEMBL16331599 | 0.91 | PIK3CA (0.44) | PIK3CAMTORPRKDCJAK3FLT3 | |
| SCHEMBL16332161 | 0.85 | CYP1A2 (0.51) | JAK3IRAK4JAK2JAK1TYK2 | |
| SCHEMBL16331299 | 0.85 | RAB9A (0.47) | PIK3CAMTORPRKDCFLT3BRAF | |
| SCHEMBL16331860 | 0.85 | PIK3CA (0.47) | PIK3CAMTORPRKDCJAK2PTPN1 | |
| SCHEMBL16332216 | 0.84 | PIK3CA (0.49) | PIK3CAMTORPRKDCJAK3IRAK4 | |
| SCHEMBL16332725 | 0.84 | MAPT (0.54) | LMNAMAPTKMT2ARAB9AMEN1 | |
| SCHEMBL16331914 | 0.82 | PIK3CA (0.46) | PIK3CAMTORPRKDCJAK3JAK1 | |
| SCHEMBL16332047 | 0.82 | PIK3CA (0.46) | PIK3CAMTORPRKDCJAK3IRAK4 | |
| SCHEMBL16332882 | 0.81 | FLT3 (0.50) | PIK3CAMTORPRKDCFLT3BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2818472-A1 | Imidazo[4,5-c]pyridine and pyrrolo[3,2-c]pyridine compounds as G-protein-coupled receptor kinase 5 (GRK5) modulators | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2014-12-31 | — | — | EP | claimed |
| EP-2818472-A1 | Imidazo[4,5-c]pyridine and pyrrolo[3,2-c]pyridine compounds as G-protein-coupled receptor kinase 5 (GRK5) modulators | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2014-12-31 | — | — | EP | disclosed |