Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 8/20 | 0.46 |
| ▸ | MTOR | P42345 | 8/20 | 0.46 |
| ▸ | PRKDC | P78527 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | TYK2 | P29597 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16332865 | 0.91 | PIK3CA (0.43) | PIK3CAMTORPRKDCALOX15MAPK1 | |
| SCHEMBL16332406 | 0.88 | SMN1; SMN2 (0.54) | ALOX15MAPK1JAK2JAK1TYK2 | |
| SCHEMBL16333060 | 0.87 | PIK3CA (0.50) | PIK3CAMTORPRKDCPIK3CDPIK3CB | |
| SCHEMBL16332216 | 0.86 | PIK3CA (0.49) | PIK3CAMTORPRKDCALOX15MAPK1 | |
| SCHEMBL16332326 | 0.86 | GABRG2 (0.52) | PIK3CAMTORPRKDCALOX15MAPK1 | |
| SCHEMBL16332334 | 0.86 | KDM1A (0.43) | ALOX15MAPK1JAK2JAK1TYK2 | |
| SCHEMBL16332080 | 0.82 | PIK3CA (0.46) | PIK3CAMTORPRKDCJAK2JAK1 | |
| SCHEMBL16332725 | 0.81 | MAPT (0.54) | NPC1RAB9AMAPTTP53KMT2A | |
| SCHEMBL16331650 | 0.80 | PIK3CA (0.44) | PIK3CAMTORPRKDCPIK3CDPIK3CB | |
| SCHEMBL16332525 | 0.80 | BRAF (0.47) | NPC1RAB9AKMT2ASMN1; SMN2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2818472-A1 | Imidazo[4,5-c]pyridine and pyrrolo[3,2-c]pyridine compounds as G-protein-coupled receptor kinase 5 (GRK5) modulators | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2014-12-31 | — | — | EP | claimed |
| EP-2818472-A1 | Imidazo[4,5-c]pyridine and pyrrolo[3,2-c]pyridine compounds as G-protein-coupled receptor kinase 5 (GRK5) modulators | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2014-12-31 | — | — | EP | disclosed |