Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 3/20 | 0.46 |
| ▸ | PRKDC | P78527 | 3/20 | 0.46 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | ATR | Q13535 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 3/20 | 0.38 |
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | IDH1 | O75874 | 3/20 | 0.36 |
| ▸ | KDM1A | O60341 | 2/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16331787 | 0.83 | MAPK9 (0.51) | PIK3CAPRKDCMTOR | |
| SCHEMBL16332845 | 0.83 | PIK3CA (0.51) | PIK3CAPRKDCTNNI3KFYNKIF11 | |
| SCHEMBL16331252 | 0.82 | JAK3 (0.46) | FLT3AURKAAURKB | |
| SCHEMBL16332011 | 0.82 | MAPT (0.43) | FLT3IDH1AURKA | |
| SCHEMBL16332558 | 0.81 | CYP1A2 (0.47) | FLT3KDM1A | |
| SCHEMBL16332095 | 0.80 | RAD52 (0.40) | PIK3CAPRKDCFYN | |
| SCHEMBL16331602 | 0.79 | FLT3 (0.44) | FYNFLT3AURKA | |
| SCHEMBL16332572 | 0.79 | PIK3CA (0.48) | PIK3CAPRKDCMTORAURKB | |
| SCHEMBL16332306 | 0.78 | RHOA (0.54) | KDM1A | |
| SCHEMBL16332832 | 0.78 | PIK3CA (0.48) | PIK3CAPRKDCMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2818472-A1 | Imidazo[4,5-c]pyridine and pyrrolo[3,2-c]pyridine compounds as G-protein-coupled receptor kinase 5 (GRK5) modulators | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2014-12-31 | — | — | EP | claimed |
| EP-2818472-A1 | Imidazo[4,5-c]pyridine and pyrrolo[3,2-c]pyridine compounds as G-protein-coupled receptor kinase 5 (GRK5) modulators | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2014-12-31 | — | — | EP | disclosed |