Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 3/20 | 0.51 |
| ▸ | PRKDC | P78527 | 3/20 | 0.51 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.45 |
| ▸ | MTOR | P42345 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | KIF11 | P52732 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.41 |
| ▸ | IDH1 | O75874 | 3/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16332219 | 0.88 | FGFR1 (0.49) | PIK3CAPRKDCFGFR1SRCHDAC6 | |
| SCHEMBL16332193 | 0.83 | PIK3CA (0.46) | PIK3CAPRKDCTNNI3KMTORFYN | |
| SCHEMBL16331647 | 0.82 | FGFR1 (0.48) | PIK3CAPRKDCFGFR1SRCHDAC6 | |
| SCHEMBL16332041 | 0.80 | PDE10A (0.44) | PIK3CAPRKDCFGFR1SRCHDAC6 | |
| SCHEMBL16333060 | 0.79 | PIK3CA (0.50) | PIK3CAPRKDCMTORFGFR1SRC | |
| SCHEMBL16332155 | 0.79 | SRC (0.47) | PIK3CAPRKDCFGFR1SRCHDAC6 | |
| SCHEMBL16332856 | 0.79 | PDGFRB (0.50) | PIK3CAPRKDCFYNNPC1RAB9A | |
| SCHEMBL16331817 | 0.74 | NPC1 (0.43) | PIK3CAPRKDCMTORFGFR1SRC | |
| SCHEMBL16331539 | 0.73 | PIK3CA (0.47) | PIK3CAPRKDCTNNI3KMTOREGFR | |
| SCHEMBL7694121 | 0.73 | CYP1A2 (0.63) | PIK3CAPRKDCFGFR1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2818472-A1 | Imidazo[4,5-c]pyridine and pyrrolo[3,2-c]pyridine compounds as G-protein-coupled receptor kinase 5 (GRK5) modulators | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2014-12-31 | — | — | EP | claimed |
| EP-2818472-A1 | Imidazo[4,5-c]pyridine and pyrrolo[3,2-c]pyridine compounds as G-protein-coupled receptor kinase 5 (GRK5) modulators | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2014-12-31 | — | — | EP | disclosed |