Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 1/20 | 0.47 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.47 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | USP2 | O75604 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | CASP1 | P29466 | 2/20 | 0.46 |
| ▸ | CASP7 | P55210 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16332292 | 0.86 | BRAF (0.47) | MEN1KMT2ACYP3A4CYP2C9CYP1A2 | |
| SCHEMBL16331800 | 0.85 | SMN1; SMN2 (0.44) | MEN1KMT2ALMNAUSP2CYP3A4 | |
| SCHEMBL16332134 | 0.85 | SMN1; SMN2 (0.52) | MEN1KMT2ANPC1RAB9ALMNA | |
| SCHEMBL16331731 | 0.84 | TRPC5 (0.47) | GABRG2GABRB3GABRA5MEN1KMT2A | |
| SCHEMBL16331495 | 0.84 | CYP1A2 (0.53) | GABRG2GABRB3GABRA5MEN1KMT2A | |
| SCHEMBL16331515 | 0.83 | GABRG2 (0.48) | GABRG2GABRB3GABRA5MEN1KMT2A | |
| SCHEMBL16331319 | 0.82 | FYN (0.47) | GABRG2GABRB3GABRA5MEN1KMT2A | |
| SCHEMBL16331460 | 0.82 | MAPT (0.47) | MEN1KMT2ANPC1RAB9ATP53 | |
| SCHEMBL16331787 | 0.82 | MAPK9 (0.51) | GABRG2GABRB3GABRA5MEN1KMT2A | |
| SCHEMBL16331635 | 0.82 | CYP1A2 (0.45) | MEN1KMT2ALMNAUSP2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2818472-A1 | Imidazo[4,5-c]pyridine and pyrrolo[3,2-c]pyridine compounds as G-protein-coupled receptor kinase 5 (GRK5) modulators | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2014-12-31 | — | — | EP | claimed |
| EP-2818472-A1 | Imidazo[4,5-c]pyridine and pyrrolo[3,2-c]pyridine compounds as G-protein-coupled receptor kinase 5 (GRK5) modulators | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2014-12-31 | — | — | EP | disclosed |