Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.42 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | PRKDC | P78527 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16331626 | 0.92 | GABRG2 (0.52) | CYP1A2CYP2C9CYP2C19KMT2AMEN1 | |
| SCHEMBL16331681 | 0.86 | CYP2C19 (0.53) | CYP1A2CYP2C9CYP2C19KMT2AMEN1 | |
| SCHEMBL16331723 | 0.86 | BRAF (0.43) | CYP1A2CYP2C9CYP2C19KMT2AMEN1 | |
| SCHEMBL16331635 | 0.86 | CYP1A2 (0.45) | CYP1A2CYP2C9CYP2C19KMT2AMEN1 | |
| SCHEMBL16332496 | 0.84 | GABRG2 (0.47) | CYP1A2CYP2C9CYP2C19KMT2AMEN1 | |
| SCHEMBL16332664 | 0.82 | GABRG2 (0.55) | FLT3GABRG2GABRB3GABRA5PIK3CA | |
| SCHEMBL16331650 | 0.82 | PIK3CA (0.44) | CYP1A2CYP2C9CYP2C19KMT2AMEN1 | |
| SCHEMBL16332080 | 0.81 | PIK3CA (0.46) | CYP1A2CYP2C9CYP2C19KMT2AMEN1 | |
| SCHEMBL16331319 | 0.81 | FYN (0.47) | CYP1A2CYP2C9CYP2C19KMT2AMEN1 | |
| SCHEMBL16331460 | 0.81 | MAPT (0.47) | KMT2AMEN1FYNPIK3CAPRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2818472-A1 | Imidazo[4,5-c]pyridine and pyrrolo[3,2-c]pyridine compounds as G-protein-coupled receptor kinase 5 (GRK5) modulators | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2014-12-31 | — | — | EP | claimed |
| EP-2818472-A1 | Imidazo[4,5-c]pyridine and pyrrolo[3,2-c]pyridine compounds as G-protein-coupled receptor kinase 5 (GRK5) modulators | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2014-12-31 | — | — | EP | disclosed |