Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 11/20 | 0.50 |
| ▸ | MTOR | P42345 | 11/20 | 0.50 |
| ▸ | PRKDC | P78527 | 1/20 | 0.50 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.48 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | PLK1 | P53350 | 1/20 | 0.45 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16332219 | 0.90 | FGFR1 (0.49) | PIK3CAPRKDCTP53CYP3A4TSHR | |
| SCHEMBL16332047 | 0.87 | PIK3CA (0.46) | PIK3CAMTORPRKDCPIK3CDPIK3CB | |
| SCHEMBL16331647 | 0.84 | FGFR1 (0.48) | PIK3CAPRKDCCYP3A4TSHRGAA | |
| SCHEMBL16332041 | 0.82 | PDE10A (0.44) | PIK3CAPRKDCCYP3A4TSHRGAA | |
| SCHEMBL16332572 | 0.82 | PIK3CA (0.48) | PIK3CAMTORPRKDCPIK3CDPIK3CB | |
| SCHEMBL16332155 | 0.81 | SRC (0.47) | PIK3CAPRKDCTP53CYP3A4TSHR | |
| SCHEMBL16332856 | 0.81 | PDGFRB (0.50) | PIK3CAPRKDCTP53KDRPLK1 | |
| SCHEMBL16332865 | 0.80 | PIK3CA (0.43) | PIK3CAMTORPRKDCPIK3CDPIK3CB | |
| SCHEMBL16331650 | 0.79 | PIK3CA (0.44) | PIK3CAMTORPRKDCPIK3CDPIK3CB | |
| SCHEMBL16332845 | 0.79 | PIK3CA (0.51) | PIK3CAMTORPRKDCFGFR1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2818472-A1 | Imidazo[4,5-c]pyridine and pyrrolo[3,2-c]pyridine compounds as G-protein-coupled receptor kinase 5 (GRK5) modulators | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2014-12-31 | — | — | EP | claimed |
| EP-2818472-A1 | Imidazo[4,5-c]pyridine and pyrrolo[3,2-c]pyridine compounds as G-protein-coupled receptor kinase 5 (GRK5) modulators | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2014-12-31 | — | — | EP | disclosed |