Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 15/20 | 0.54 |
| ▸ | CCND1 | P24385 | 10/20 | 0.54 |
| ▸ | CDK2 | P24941 | 6/20 | 0.54 |
| ▸ | CDK1 | P06493 | 4/20 | 0.54 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.54 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.54 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.51 |
| ▸ | FGFR2 | P21802 | 4/20 | 0.51 |
| ▸ | FGFR4 | P22455 | 4/20 | 0.51 |
| ▸ | FGFR3 | P22607 | 4/20 | 0.51 |
| ▸ | CCND2 | P30279 | 4/20 | 0.51 |
| ▸ | CCND3 | P30281 | 4/20 | 0.51 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.51 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.51 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.49 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.49 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.49 |
| ▸ | IGF1R | P08069 | 1/20 | 0.49 |
| ▸ | CDK6 | Q00534 | 5/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1633643 | 0.94 | CDK4 (0.51) | CDK4CCND1CDK2CDK1CCNB1 | |
| SCHEMBL1634127 | 0.93 | CDK4 (0.49) | CDK4CCND1CDK2CDK1CCNB1 | |
| SCHEMBL1633235 | 0.89 | CDK4 (0.62) | CDK4CCND1CDK2CDK1CCNB1 | |
| SCHEMBL1633607 | 0.86 | JAK2 (0.51) | CDK4CCND1CDK2CDK1CCNB1 | |
| SCHEMBL1633571 | 0.84 | TBK1 (0.54) | CDK4CCND1CDK2CDK1CCNB1 | |
| SCHEMBL1632091 | 0.84 | IKBKB (0.47) | CDK4CCND1CDK2CDK1CCNB1 | |
| SCHEMBL1632510 | 0.83 | IGF1R (0.51) | CDK2CCNE1CCNA2CCNA1IGF1R | |
| SCHEMBL13498236 | 0.83 | CDK4 (0.51) | CDK4CCND1CDK2CDK1CCNB1 | |
| SCHEMBL1634274 | 0.83 | CDK4 (0.51) | CDK4CCND1CDK2CDK1CCNB1 | |
| SCHEMBL1633501 | 0.82 | LRRK2 (0.51) | CDK4CCND1CDK2CDK1CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-20100048561-A1 | QUINAZOLINES FOR PDK1 INHIBITION | NOVARTIS VACCINES & DIAGNOSTICS, INC. (US) | 2010-02-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048561-A1 | QUINAZOLINES FOR PDK1 INHIBITION | PDK1, PDK2, PDK3 | CDK4 24/4885CCND1 618/4885CDK2 29/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.