Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 5/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.35 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16887438 | 0.81 | CYP1A2 (0.37) | PIK3CALMNACYP2C19SMN1; SMN2SCN9A | |
| SCHEMBL23525752 | 0.80 | CCR4 (0.37) | PIK3CALMNAKMT2ASCN9APIK3CD | |
| SCHEMBL30791387 | 0.80 | CCR4 (0.37) | PIK3CALMNAKMT2ASCN9APIK3CD | |
| SCHEMBL6679844 | 0.77 | NCF1 (0.39) | MAPK8MAPK9ALDH1A1CYP3A4 | |
| SCHEMBL10264228 | 0.77 | KMT2A (0.42) | LMNASMN1; SMN2MEN1KMT2ASCN9A | |
| SCHEMBL15508008 | 0.74 | KDM4E (0.38) | LMNACYP2C19SMN1; SMN2MEN1KMT2A | |
| SCHEMBL31326437 | 0.72 | P4HTM (0.41) | SCN9ACA1CA2MAPK8MAPK9 | |
| SCHEMBL16741183 | 0.71 | POLB (0.43) | SMN1; SMN2MEN1KMT2ABRD4 | |
| SCHEMBL19172606 | 0.69 | HCAR3 (0.42) | LMNACYP2C19GAAALDH1A1CYP3A4 | |
| SCHEMBL7351894 | 0.68 | CA12 (0.46) | PIK3CALMNACYP2C19SMN1; SMN2PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2491023-B1 | COUMARIN COMPOUNDS AS RECEPTOR MODULATORS WITH THERAPEUTIC UTILITY | ALLERGAN INC (US) | 2014-12-31 | — | — | EP | disclosed |