SCHEMBL6679844

SCHEMBL6679844

CNc1ccc(N)c(OC)n1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NCF1 P14598 3/20 0.39
ALDH1A1 P00352 4/20 0.36
CYP2D6 P10635 2/20 0.36
CYP3A4 P08684 2/20 0.36
CYP1A2 P05177 1/20 0.36
MAPK8 P45983 1/20 0.36
MAPK9 P45984 1/20 0.36
NUDT1 P36639 3/20 0.33
MAOB P27338 1/20 0.33
ATM Q13315 1/20 0.33
MAPT P10636 1/20 0.33
CASP1 P29466 1/20 0.33
TSHR P16473 1/20 0.32
HSD17B10 Q99714 1/20 0.32
TDP1 Q9NUW8 1/20 0.32
APP P05067 2/20 0.32
GRM4 Q14833 1/20 0.32
AURKA O14965 1/20 0.32
TTK P33981 1/20 0.32
AURKB Q96GD4 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16333322 0.77 PIK3CA (0.37) ALDH1A1CYP3A4MAPK8MAPK9
SCHEMBL6782662 0.76 NCF1 (0.39) NCF1ALDH1A1CYP2D6CYP3A4CYP1A2
SCHEMBL29513484 0.76 NCF1 (0.39) NCF1ALDH1A1CYP2D6CYP3A4CYP1A2
SCHEMBL25333071 0.76 NCF1 (0.39) NCF1ALDH1A1CYP2D6CYP3A4CYP1A2
SCHEMBL19172606 0.75 HCAR3 (0.42) NCF1ALDH1A1CYP2D6CYP3A4CYP1A2
SCHEMBL24160900 0.74 NCF1 (0.45) NCF1CYP3A4CYP1A2NUDT1MAOB
SCHEMBL13746013 0.74 NCF1 (0.42) NCF1ALDH1A1CYP3A4CYP1A2MAPT
SCHEMBL3942677 0.72 NCF1 (0.43) NCF1CYP3A4CYP1A2NUDT1MAOB
SCHEMBL94534 0.72 NCF1 (0.43) NCF1CYP3A4CYP1A2NUDT1MAOB
SCHEMBL1909505 0.72 APOBEC3A (0.40) ALDH1A1CYP3A4ATMMAPTCASP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1250912-B1 Hair dye composition KPSS KAO GMBH (DE) 2004-09-15 EP disclosed
EP-1250912-A1 Hair dye composition GOLDWELL GmbH (DE) 2002-10-23 EP disclosed