Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 5/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | GFER | P55789 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | S100B | P04271 | 1/20 | 0.55 |
| ▸ | NOS2 | P35228 | 1/20 | 0.54 |
| ▸ | GABRP | O00591 | 1/20 | 0.53 |
| ▸ | GABRD | O14764 | 1/20 | 0.53 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.53 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.53 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.53 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.53 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.53 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.53 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.53 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.53 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30484136 | 0.93 | RECQL (0.67) | RECQLMAPTPOLBSMN1; SMN2GFER | |
| SCHEMBL31000389 | 0.93 | RECQL (0.67) | RECQLMAPTPOLBSMN1; SMN2GFER | |
| SCHEMBL145366 | 0.93 | RECQL (0.67) | RECQLMAPTPOLBSMN1; SMN2GFER | |
| Hydrochloric Acid SCHEMBL27581315 | 0.92 | RECQL (0.65) | RECQLMAPTPOLBSMN1; SMN2GFER | |
| Hydrazine SCHEMBL11821861 | 0.92 | RECQL (0.65) | RECQLMAPTPOLBSMN1; SMN2GFER | |
| Acetamide SCHEMBL28069463 | 0.87 | ALDH1A1 (0.56) | RECQLMAPTSMN1; SMN2S100BGABRP | |
| SCHEMBL6351799 | 0.84 | RECQL (0.64) | RECQLMAPTPOLBSMN1; SMN2GFER | |
| SCHEMBL28751447 | 0.84 | RECQL (0.56) | RECQLMAPTPOLBSMN1; SMN2GFER | |
| SCHEMBL9853497 | 0.82 | SMN1; SMN2 (0.46) | RECQLMAPTPOLBSMN1; SMN2GFER | |
| SCHEMBL9853525 | 0.82 | SMN1; SMN2 (0.46) | RECQLMAPTPOLBSMN1; SMN2GFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9630909-B2 | Process for the preparation of nepafenac | MYLAN LABORATORIES LTD (IN) | 2017-04-25 | — | — | US | disclosed |
| US-20160214927-A1 | Process for the preparation of nepafenac | MYLAN LABORATORIES LTD, (IN) | 2016-07-28 | — | — | US | disclosed |
| EP-3013790-A1 | PROCESS FOR THE PREPARATION OF NEPAFENAC | Mylan Laboratories Ltd. (IN) | 2016-05-04 | — | — | EP | disclosed |
| WO-2014207769-A1 | PROCESS FOR THE PREPARATION OF NEPAFENAC | MYLAN LABORATORIES LTD (IN) | 2014-12-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160214927-A1 | Process for the preparation of nepafenac | SCN2B, SCN3A, SCN2A | RECQL 3728/4885MAPT 1784/4885POLB 2171/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.