⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27852103 | 0.83 | ALDH1A1 (0.43) | — | |
| SCHEMBL27478065 | 0.83 | ALDH1A1 (0.43) | — | |
| SCHEMBL5086027 | 0.79 | — | — | |
| SCHEMBL3559527 | 0.79 | — | — | |
| SCHEMBL28140898 | 0.79 | — | — | |
| SCHEMBL11688470 | 0.79 | PKM (0.38) | — | |
| SCHEMBL28000724 | 0.78 | HTT (0.45) | — | |
| SCHEMBL27521615 | 0.78 | ALDH1A1 (0.40) | — | |
| SCHEMBL7499725 | 0.78 | HTT (0.45) | — | |
| Hydrochloric Acid SCHEMBL28248957 | 0.78 | ALDH1A1 (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2286670-A | — | — | None | — | — | JP | disclosed |
| JP-4049290-A | — | — | None | — | — | JP | disclosed |
| US-7932386-B2 | Preparation of 2-amino-thiazole-5-carboxylic-acid derivatives | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-04-26 | — | — | US | disclosed |
| EP-1919885-B1 | PREPARATION OF 2-AMINO-THIAZOLE-5-CARBOXYLIC-ACID DERIVATIVES | BRISTOL MYERS SQUIBB CO (US) | 2010-04-28 | — | — | EP | disclosed |
| US-20090030203-A1 | PREPARATION OF 2-AMINO-THIAZOLE-5-CARBOXYLIC-ACID DERIVATIVES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-01-29 | — | — | US | disclosed |
| US-7408069-B2 | Preparation of 2-amino-thiazole-5-carboxylic-acid derivatives | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-08-05 | — | — | US | disclosed |
| EP-1919885-A1 | PREPARATION OF 2-AMINO-THIAZOLE-5-CARBOXYLIC-ACID DERIVATIVES | Brystol-Myers Squibb Company (US) | 2008-05-14 | — | — | EP | disclosed |
| WO-2007019210-A1 | PREPARATION OF 2-AMINO-THIAZOLE-5-CARBOXYLIC-ACID DERIVATIVES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-02-15 | — | — | WO | disclosed |
| US-20070037978-A1 | Amidating chloro-, methyl-, methoxy, ethyl- or ethoxy-substituted aniline with 2,3-dichloroacryloyl chloride, alkanoate salt and inorganic base to form an N-phenyl-2-chloro-3,3-dimethoxypropionamide (that is also claimed), which is reacted with thiourea to form a N-phenyl-2-aminothiazol-5-ylcarboxamide | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-02-15 | — | — | US | disclosed |
| JP-H0449290-A | PRODUCTION OF OPTICALLY ACTIVE AMIDE DERIVATIVE | MITSUI TOATSU CHEM INC | 1992-02-18 | — | — | JP | disclosed |
| JP-H02286670-A | MINERAL ACID SALTS OF THIAZOLE CARBOXYLIC ACID CHLORIDE AND PRODUCTION THEREOF | MITSUI TOATSU CHEM INC | 1990-11-26 | — | — | JP | disclosed |