Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Proline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 3/20 | 0.47 |
| ▸ | METAP1 | P53582 | 3/20 | 0.47 |
| ▸ | ELANE | P08246 | 1/20 | 0.44 |
| ▸ | SSTR4 | P31391 | 3/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.40 |
| ▸ | ACP3 | P15309 | 1/20 | 0.40 |
| ▸ | SCN4A | P35499 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CASR | P41180 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Proline SCHEMBL18438885 | 0.82 | ALDH1A1 (0.47) | ELANESCN4AALDH1A1KDM4EHPGD | |
| Proline SCHEMBL18438884 | 0.82 | ALDH1A1 (0.47) | ELANESCN4AALDH1A1KDM4EHPGD | |
| Timonacic SCHEMBL10716802 | 0.81 | METAP2 (0.42) | METAP2METAP1SSTR4CYP2D6ALDH1A1 | |
| Propofol SCHEMBL2678239 | 0.78 | SLC6A2 (0.49) | ELANECYP2D6SCN4AHPGD | |
| Proline SCHEMBL28101824 | 0.76 | NOS2 (0.40) | ELANECYP2D6SCN4AMEN1KMT2A | |
| Urea SCHEMBL15059374 | 0.76 | MAPT (0.59) | METAP2METAP1SSTR4CYP2D6ALDH1A1 | |
| Urea SCHEMBL16340248 | 0.76 | MAPT (0.59) | METAP2METAP1SSTR4CYP2D6ALDH1A1 | |
| Proline SCHEMBL11433574 | 0.75 | SLC1A3 (0.47) | — | |
| SCHEMBL128713 | 0.74 | ALDH1A1 (0.56) | CYP2D6ALDH1A1HPGD | |
| SCHEMBL353568 | 0.74 | ALDH1A1 (0.56) | CYP2D6ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2794621-B1 | NOVEL ORGANOSILICA COMPOUNDS | UNIV GENT (BE) | 2018-09-26 | — | — | EP | disclosed |
| US-9181282-B2 | Organosilica compounds | UNIVERSITEIT GENT (BE) | 2015-11-10 | — | — | US | disclosed |
| US-20150005525-A1 | NOVEL ORAGNOSILICA COMPOUNDS | UNIVERSITEIT GENT (BE) | 2015-01-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150005525-A1 | NOVEL ORAGNOSILICA COMPOUNDS | ORC3, ORMDL3, OR10J3 | METAP2 537/4885METAP1 891/4885ELANE 1637/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.