Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | ACP3 | P15309 | 2/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.40 |
| ▸ | PRCP | P42785 | 1/20 | 0.39 |
| ▸ | APAF1 | O14727 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1634184 | 1.00 | GAA (0.45) | GAAL3MBTL1SIGMAR1RECQLACP3 | |
| SCHEMBL27837886 | 1.00 | GAA (0.45) | GAAL3MBTL1SIGMAR1RECQLACP3 | |
| SCHEMBL2547630 | 0.87 | GAA (0.45) | GAAL3MBTL1SIGMAR1RECQLACP3 | |
| SCHEMBL12410226 | 0.85 | GAA (0.46) | GAAL3MBTL1SIGMAR1RECQLACP3 | |
| SCHEMBL1559707 | 0.81 | GAA (0.42) | GAAL3MBTL1SIGMAR1RECQLACP3 | |
| SCHEMBL12759518 | 0.81 | GAA (0.42) | GAAL3MBTL1SIGMAR1RECQLACP3 | |
| SCHEMBL1559844 | 0.81 | GAA (0.42) | GAAL3MBTL1SIGMAR1RECQLACP3 | |
| SCHEMBL24129831 | 0.77 | GAA (0.52) | GAAL3MBTL1SIGMAR1RECQLACP3 | |
| SCHEMBL4273016 | 0.74 | SIGMAR1 (0.63) | SIGMAR1ACP3LMNATRPA1APAF1 | |
| SCHEMBL17530043 | 0.74 | SIGMAR1 (0.63) | SIGMAR1ACP3LMNATRPA1APAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2303867-B1 | PYRAZINONE MODULATOR OF CORTICOTROPIN-RELEASING FACTOR RECEPTOR ACTIVITY | BRISTOL MYERS SQUIBB CO (US) | 2014-12-17 | — | — | EP | disclosed |
| CN-102171205-B | Pyrazinone modulators of corticotropin releasing factor receptor activity | BRISTOL MYERS SQUIBB CO | 2013-08-07 | — | — | CN | disclosed |
| US-8372847-B2 | Pyrazinone modulator of corticotropin-releasing factor receptor activity | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-02-12 | — | — | US | disclosed |
| CN-102171205-A | Pyrazinone modulators of corticotropin releasing factor receptor activity | BRISTOL MYERS SQUIBB CO | 2011-08-31 | — | — | CN | disclosed |
| US-20110166160-A1 | Pyrazinone Modulator of Corticotropin-Releasing Factor Receptor Activity | BRISTOL-MYERS SQUIBB COMPANY | 2011-07-07 | — | — | US | disclosed |
| US-7932256-B2 | (S)-4-(1-cyclopropyl-2-methoxyethyl)-6-(6-(difluoromethoxy)-2,5-dimethylpyridin-3-ylamino)-5-oxo-4,5-dihydropyrazine-2-carbonitrile: a pyrazinone modulator of corticotropin-releasing factor receptor activity | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-04-26 | — | — | US | disclosed |
| US-20100029684-A1 | Pyrazinone Modulator of Corticotropin-Releasing Factor Receptor Activity | BRISTOL-MYERS SQUIBB COMPANY | 2010-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029684-A1 | Pyrazinone Modulator of Corticotropin-Releasing Factor Receptor Activity | CRH, CRHR1, CRHR2 | GAA 4565/4885L3MBTL1 4861/4885SIGMAR1 202/4885 |
| US-20110166160-A1 | Pyrazinone Modulator of Corticotropin-Releasing Factor Receptor Activity | CRH, CRHR1, CRHR2 | GAA 4565/4885L3MBTL1 4861/4885SIGMAR1 202/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.