Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.49 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | XDH | P47989 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.40 |
| ▸ | IDO1 | P14902 | 3/20 | 0.39 |
| ▸ | AGXT | P21549 | 2/20 | 0.39 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.38 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | TDO2 | P48775 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16348018 | 0.82 | CYP11B1 (0.50) | CYP11B1CYP11B2SMN1; SMN2TDP1TAAR1 | |
| SCHEMBL6813771 | 0.81 | ENPP2 (0.42) | TAAR1MAPK1KMT2A | |
| SCHEMBL27895616 | 0.81 | L3MBTL1 (0.55) | CYP11B1CYP11B2SMN1; SMN2IDO1MEN1 | |
| SCHEMBL28827046 | 0.81 | CYP11B1 (0.49) | CYP11B1CYP11B2TDP1MAOBMEN1 | |
| SCHEMBL583731 | 0.79 | CYP19A1 (0.48) | CYP11B1CYP11B2SMN1; SMN2MEN1KMT2A | |
| SCHEMBL27680990 | 0.77 | KDM4E (0.49) | TAAR1IDO1GPR55ALDH1A1 | |
| SCHEMBL2699902 | 0.77 | CYP19A1 (0.52) | CYP11B1CYP11B2KMT2AALDH1A1 | |
| SCHEMBL16129781 | 0.73 | HTT (0.59) | CYP11B1ADRA2CCYP11B2SMN1; SMN2TDP1 | |
| SCHEMBL957615 | 0.72 | KMT2A (0.49) | SMN1; SMN2TDP1TAAR1IDO1MAPK1 | |
| SCHEMBL11031678 | 0.72 | CYP11B1 (0.50) | CYP11B1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3016934-A2 | HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF SUMO ACTIVATING ENZYME | Millennium Pharmaceuticals, Inc. (US) | 2016-05-11 | — | — | EP | disclosed |
| CN-105492429-A | Heteroaryl inhibitors of SUMO activating enzyme | MILLENNIUM PHARM INC | 2016-04-13 | — | — | CN | disclosed |
| WO-2015002994-A2 | HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF SUMO ACTIVATING ENZYME | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2015-01-08 | — | — | WO | disclosed |