Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.50 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | DBH | P09172 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | PNMT | P11086 | 1/20 | 0.43 |
| ▸ | TYR | P14679 | 1/20 | 0.42 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.42 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.42 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.42 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL583731 | 0.84 | CYP19A1 (0.48) | CYP11B1CYP11B2ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL28827046 | 0.82 | CYP11B1 (0.49) | CYP11B1CYP11B2ALDH1A1TDP1MEN1 | |
| SCHEMBL6813771 | 0.82 | ENPP2 (0.42) | HTTLMNAKDM4EMAPTTAAR1 | |
| SCHEMBL16347306 | 0.82 | CYP11B1 (0.49) | CYP11B1CYP11B2ALDH1A1SMN1; SMN2TDP1 | |
| SCHEMBL27895616 | 0.82 | L3MBTL1 (0.55) | CYP11B1CYP11B2ALDH1A1HTTNPC1 | |
| SCHEMBL958636 | 0.80 | CYP2A6 (0.43) | CYP11B1CYP11B2ALDH1A1HTTNPC1 | |
| SCHEMBL957615 | 0.80 | KMT2A (0.49) | HTTNPC1LMNASMN1; SMN2SIGMAR1 | |
| SCHEMBL27680990 | 0.78 | KDM4E (0.49) | ALDH1A1HTTLMNAKDM4EMAPT | |
| SCHEMBL2699902 | 0.78 | CYP19A1 (0.52) | CYP11B1CYP11B2ALDH1A1KMT2A | |
| SCHEMBL16347168 | 0.75 | HTT (0.59) | CYP11B1CYP11B2ALDH1A1HTTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3016934-A2 | HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF SUMO ACTIVATING ENZYME | Millennium Pharmaceuticals, Inc. (US) | 2016-05-11 | — | — | EP | disclosed |
| CN-105492429-A | Heteroaryl inhibitors of SUMO activating enzyme | MILLENNIUM PHARM INC | 2016-04-13 | — | — | CN | disclosed |
| WO-2015002994-A2 | HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF SUMO ACTIVATING ENZYME | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2015-01-08 | — | — | WO | disclosed |
| CN-103025724-A | Piperidine derivatives | HOFFMANN LA ROCHE | 2013-04-03 | — | — | CN | disclosed |
| CN-102209537-A | Heterocyclic gamma secretase modulators | HOFFMANN LA ROCHE | 2011-10-05 | — | — | CN | disclosed |