Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.46 |
| ▸ | XDH | P47989 | 1/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | TDO2 | P48775 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5095183 | 0.80 | TSHR (0.45) | MEN1KMT2ACYP19A1POLBKDM4E | |
| SCHEMBL23003843 | 0.72 | SMN1; SMN2 (0.51) | MEN1KMT2ACYP11B1ADRA2CCYP11B2 | |
| SCHEMBL28603456 | 0.70 | MGLL (0.39) | MEN1KMT2APOLBALDH1A1LMNA | |
| SCHEMBL26307648 | 0.70 | MEN1 (0.62) | MEN1KMT2AGPR55SMN1; SMN2CYP19A1 | |
| SCHEMBL16344890 | 0.70 | MEN1 (0.49) | MEN1KMT2AGPR55XDHCYP11B1 | |
| SCHEMBL16347306 | 0.69 | CYP11B1 (0.49) | MEN1KMT2AGPR55XDHCYP11B1 | |
| SCHEMBL29699803 | 0.69 | PTGER1 (0.69) | MEN1KMT2APTGDR2 | |
| SCHEMBL16102428 | 0.65 | CYP19A1 (0.59) | MEN1KMT2AXDHCYP11B1ADRA2C | |
| SCHEMBL16129815 | 0.65 | CYP11B1 (0.65) | XDHCYP11B1ADRA2CCYP11B2SMN1; SMN2 | |
| SCHEMBL17731599 | 0.65 | MEN1 (0.48) | MEN1KMT2AGPR55XDHCYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3016934-A2 | HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF SUMO ACTIVATING ENZYME | Millennium Pharmaceuticals, Inc. (US) | 2016-05-11 | — | — | EP | disclosed |
| WO-2015002994-A2 | HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF SUMO ACTIVATING ENZYME | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2015-01-08 | — | — | WO | disclosed |