Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | SLC13A5 | Q86YT5 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA4 | P22748 | 1/20 | 0.43 |
| ▸ | CA6 | P23280 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | TPMT | P51580 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 3/20 | 0.43 |
| ▸ | PPARA | Q07869 | 3/20 | 0.43 |
| ▸ | PPARD | Q03181 | 1/20 | 0.43 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14934285 | 0.83 | PPARA (0.53) | ALDH1A1CYP2C9KDM4EHSD17B10PPARG | |
| SCHEMBL3599895 | 0.83 | CYP2C9 (0.59) | ALDH1A1L3MBTL1CYP2C9KDM4EHSD17B10 | |
| SCHEMBL21939299 | 0.83 | CYP2C9 (0.49) | ALDH1A1L3MBTL1CYP2C9KDM4EHSD17B10 | |
| SCHEMBL20014777 | 0.82 | PTGDR2 (0.43) | ALDH1A1L3MBTL1CYP2C9KDM4EHSD17B10 | |
| SCHEMBL1333446 | 0.82 | HSD11B1 (0.49) | ALDH1A1KDM4EHSD17B10CA12CA1 | |
| SCHEMBL2563025 | 0.81 | CA12 (0.53) | ALDH1A1L3MBTL1CYP2C9CA12CA1 | |
| SCHEMBL13180019 | 0.80 | CYP2C9 (0.45) | ALDH1A1CYP2C9KDM4EHSD17B10PPARG | |
| SCHEMBL4133841 | 0.80 | PPARA (0.49) | ALDH1A1L3MBTL1CYP2C9KDM4EHSD17B10 | |
| Bicarbonate SCHEMBL5984739 | 0.80 | HSD11B1 (0.47) | ALDH1A1KDM4EHSD17B10CA12CA1 | |
| SCHEMBL16342281 | 0.80 | ACHE (0.46) | ACHEALDH1A1L3MBTL1CYP2C9KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140171427-A1 | Heterocyclic chromene-spirocyclic piperidine amides as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-06-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140171427-A1 | Heterocyclic chromene-spirocyclic piperidine amides as modulators of ion channels | KCNJ2, TRPV1, KCNJ1 | ACHE 725/4885ALDH1A1 1614/4885L3MBTL1 4783/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.