Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Leucine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.46 |
| ▸ | BHMT | Q93088 | 10/20 | 0.40 |
| ▸ | SLC1A3 | P43003 | 3/20 | 0.39 |
| ▸ | SLC1A2 | P43004 | 3/20 | 0.39 |
| ▸ | BHMT2 | Q9H2M3 | 1/20 | 0.38 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.37 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 2/20 | 0.33 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Leucine SCHEMBL27814601 | 0.92 | SLC7A5 (0.55) | SLC7A5BHMTSLC1A3SLC1A2BHMT2 | |
| Leucine SCHEMBL27487105 | 0.92 | SLC7A5 (0.55) | SLC7A5BHMTSLC1A3SLC1A2BHMT2 | |
| Leucine SCHEMBL15322444 | 0.91 | SLC7A5 (0.53) | SLC7A5BHMTSLC1A3SLC1A2BHMT2 | |
| Leucine SCHEMBL15322442 | 0.91 | SLC7A5 (0.53) | SLC7A5BHMTSLC1A3SLC1A2BHMT2 | |
| Methionine SCHEMBL4361132 | 0.91 | BHMT (0.46) | BHMTSLC1A3SLC1A2BHMT2SLC1A1 | |
| Racemethionine SCHEMBL4361129 | 0.91 | BHMT (0.46) | BHMTSLC1A3SLC1A2BHMT2SLC1A1 | |
| Racemethionine SCHEMBL692979 | 0.88 | BHMT (0.40) | BHMTSLC1A3SLC1A2BHMT2SLC1A1 | |
| Methionine SCHEMBL5582474 | 0.88 | BHMT (0.40) | BHMTSLC1A3SLC1A2BHMT2SLC1A1 | |
| Methionine SCHEMBL692981 | 0.88 | BHMT (0.40) | BHMTSLC1A3SLC1A2BHMT2SLC1A1 | |
| Leucine SCHEMBL15323686 | 0.88 | SLC7A5 (0.56) | SLC7A5BHMTSLC1A3SLC1A2BHMT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8933193-B2 | Lantibiotics and uses thereof | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2015-01-13 | — | — | US | disclosed |
| US-20110305763-A1 | LANTIBIOTICS AND USES THEREOF | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2011-12-15 | — | — | US | disclosed |