Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 3/20 | 0.32 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.31 |
| ▸ | NAAA | Q02083 | 3/20 | 0.31 |
| ▸ | PLG | P00747 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13685693 | 0.94 | F2 (0.37) | GAAF2F10PRSS1BACE1 | |
| SCHEMBL16349811 | 0.85 | F2 (0.42) | GAAF2F10PRSS1 | |
| SCHEMBL8291443 | 0.79 | F2 (0.43) | GAAF2F10PRSS1 | |
| SCHEMBL16315715 | 0.78 | GAA (0.35) | GAAF2F10PRSS1BACE1 | |
| SCHEMBL16349581 | 0.78 | GAA (0.35) | GAAF2F10PRSS1BACE1 | |
| SCHEMBL16349734 | 0.78 | GAA (0.35) | GAAF2F10PRSS1BACE1 | |
| SCHEMBL16349612 | 0.78 | CASP3 (0.41) | BACE1 | |
| SCHEMBL12856080 | 0.78 | F2 (0.35) | GAAF2F10PRSS1BACE1 | |
| SCHEMBL12856063 | 0.78 | MME (0.31) | — | |
| SCHEMBL13685696 | 0.77 | ELANE (0.37) | BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7592419-B2 | Macrocyclic inhibitors of hepatitis C virus NS3-serine protease | SCHERING CORPORATION (US) | 2009-09-22 | — | — | US | disclosed |