Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | NAAA | Q02083 | 4/20 | 0.33 |
| ▸ | BACE1 | P56817 | 4/20 | 0.32 |
| ▸ | PLG | P00747 | 1/20 | 0.32 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.31 |
| ▸ | CTSD | P07339 | 2/20 | 0.31 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.31 |
| ▸ | REN | P00797 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8291503 | 0.87 | F2 (0.41) | F2F10PRSS1GAAPLG | |
| SCHEMBL13685100 | 0.80 | F2 (0.33) | F2F10PRSS1GAABACE1 | |
| SCHEMBL16349820 | 0.78 | GAA (0.35) | F2F10PRSS1GAANAAA | |
| SCHEMBL13685693 | 0.77 | F2 (0.37) | F2F10PRSS1GAANAAA | |
| SCHEMBL16349612 | 0.77 | CASP3 (0.41) | BACE1 | |
| SCHEMBL13685703 | 0.76 | CASP3 (0.40) | BACE1 | |
| SCHEMBL16349811 | 0.75 | F2 (0.42) | F2F10PRSS1GAA | |
| SCHEMBL12856082 | 0.74 | CTSD (0.33) | F2F10PRSS1GAABACE1 | |
| SCHEMBL8290545 | 0.74 | CTSD (0.33) | F2F10PRSS1GAABACE1 | |
| SCHEMBL8289304 | 0.74 | F2 (0.32) | F2F10PRSS1GAABACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1664092-B1 | MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS NS3 SERINE PROTEASE | SCHERING CORP (US) | 2011-02-02 | — | — | EP | disclosed |