SCHEMBL16351982

SCHEMBL16351982

Cc1ccc(-c2cc(O)cc(C(=O)O)c2)cc1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HCAR1 Q9BXC0 2/20 0.60
DHODH Q02127 2/20 0.58
AURKA O14965 1/20 0.58
TPX2 Q9ULW0 1/20 0.58
EGFR P00533 1/20 0.58
RXRA P19793 2/20 0.56
RXRB P28702 2/20 0.56
CA12 O43570 1/20 0.54
CA1 P00915 1/20 0.54
CA2 P00918 1/20 0.54
CA7 P43166 1/20 0.54
CA9 Q16790 1/20 0.54
CA14 Q9ULX7 1/20 0.54
CTRC Q99895 1/20 0.53
ALDH1A1 P00352 1/20 0.52
SMN1; SMN2 Q16637 1/20 0.52
MCL1 Q07820 1/20 0.51
FABP1 P07148 1/20 0.51
P2RY14 Q15391 1/20 0.51
AKR1C2 P52895 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16196117 0.88 DHODH (0.70) DHODHEGFRRXRARXRBCTRC
SCHEMBL1495453 0.88 DHODH (0.70) DHODHRXRARXRBCTRCALDH1A1
SCHEMBL18703888 0.86 EGFR (0.63) HCAR1DHODHAURKATPX2EGFR
SCHEMBL30758058 0.85 HCAR1 (0.77) HCAR1DHODHAURKATPX2EGFR
SCHEMBL7823500 0.84 ALDH1A1 (0.65) HCAR1DHODHRXRARXRBCTRC
SCHEMBL2555497 0.84 EGFR (0.61) HCAR1DHODHAURKATPX2EGFR
SCHEMBL18706550 0.82 EGFR (0.75) HCAR1DHODHAURKATPX2EGFR
SCHEMBL29419324 0.82 EGFR (0.75) HCAR1DHODHAURKATPX2EGFR
SCHEMBL27176495 0.81 RXRA (0.67) HCAR1DHODHAURKATPX2EGFR
SCHEMBL2979964 0.81 DHODH (0.62) DHODHRXRARXRBCTRCALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9567526-B2 Polymerizable compounds and the use thereof in liquid-crystal displays MERCK PATENT GMBH (DE) 2017-02-14 US disclosed
US-20140375943-A1 POLYMERIZABLE COMPOUNDS AND THE USE THEREOF IN LIQUID-CRYSTAL DISPLAYS MERCK PATENT GMBH (DE) 2014-12-25 US disclosed