Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 6/20 | 0.70 |
| ▸ | KDM4A | O75164 | 1/20 | 0.59 |
| ▸ | KDM5A | P29375 | 1/20 | 0.59 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.59 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.59 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16341566 | 0.99 | ALOX5 (0.68) | ALOX5KDM4AKDM5AKDM4CPHF8 | |
| SCHEMBL16792012 | 0.94 | KDM4A (0.68) | ALOX5KDM4AKDM5AKDM4CPHF8 | |
| SCHEMBL16352102 | 0.93 | ALOX5 (0.72) | ALOX5KDM4AKDM5AKDM4CPHF8 | |
| SCHEMBL16341565 | 0.88 | ALOX5 (0.65) | ALOX5KDM4AKDM5AKDM4CPHF8 | |
| SCHEMBL16352103 | 0.84 | ALOX5 (0.52) | ALOX5 | |
| SCHEMBL9833833 | 0.83 | ALOX5 (1.00) | ALOX5KDM4AKDM5AKDM4CPHF8 | |
| SCHEMBL16352089 | 0.83 | ALOX5 (0.64) | ALOX5KDM4AKDM5AKDM4CPHF8 | |
| SCHEMBL16322681 | 0.82 | ALOX5 (0.51) | ALOX5 | |
| SCHEMBL10692283 | 0.82 | ALOX5 (0.79) | ALOX5KDM4AKDM5AKDM4CPHF8 | |
| SCHEMBL9834381 | 0.81 | ALOX5 (0.77) | ALOX5KDM4AKDM5AKDM4CPHF8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9593136-B2 | Compounds for inhibiting 1-deoxy-D-xylulose-5-phosphate reductoisomerase | THE GEORGE WASHINGTON UNIVERSITY (US) | 2017-03-14 | — | — | US | disclosed |
| US-9593136-B2 | Compounds for inhibiting 1-deoxy-D-xylulose-5-phosphate reductoisomerase | THE GEORGE WASHINGTON UNIVERSITY (US) | 2017-03-14 | — | — | US | disclosed |
| US-20140378418-A1 | COMPOUNDS FOR INHIBITING 1-DEOXY-D-XYLULOSE-5-PHOSPHATE REDUCTOISOMERASE | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | 2014-12-25 | — | — | US | disclosed |
| US-20140378418-A1 | COMPOUNDS FOR INHIBITING 1-DEOXY-D-XYLULOSE-5-PHOSPHATE REDUCTOISOMERASE | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | 2014-12-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140378418-A1 | COMPOUNDS FOR INHIBITING 1-DEOXY-D-XYLULOSE-5-PHOSPHATE REDUCTOISOMERASE | DCXR, G6PD, GRHPR | ALOX5 1559/4885KDM4A 3340/4885KDM5A 1117/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.