Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 3/20 | 0.52 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.52 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.48 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.46 |
| ▸ | MMP1 | P03956 | 1/20 | 0.45 |
| ▸ | MMP3 | P08254 | 1/20 | 0.45 |
| ▸ | MMP7 | P09237 | 1/20 | 0.45 |
| ▸ | MMP9 | P14780 | 1/20 | 0.45 |
| ▸ | MMP13 | P45452 | 1/20 | 0.45 |
| ▸ | KLK7 | P49862 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | DRD4 | P21917 | 2/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.42 |
| ▸ | STS | P08842 | 1/20 | 0.42 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1393680 | 1.00 | NR1H2 (0.52) | NR1H2NR1H3AGTR2KLK5MMP1 | |
| SCHEMBL1950995 | 0.91 | NR1H2 (0.46) | NR1H2NR1H3KLK5KLK7GPR119 | |
| SCHEMBL12549137 | 0.91 | NR1H2 (0.46) | NR1H2NR1H3KLK5KLK7GPR119 | |
| SCHEMBL565036 | 0.90 | AGTR2 (0.60) | NR1H2NR1H3AGTR2MMP1MMP3 | |
| SCHEMBL1634212 | 0.90 | AGTR2 (0.60) | NR1H2NR1H3AGTR2MMP1MMP3 | |
| SCHEMBL21886385 | 0.89 | NR1H2 (0.50) | NR1H2NR1H3AGTR2KLK5KLK7 | |
| SCHEMBL15147916 | 0.89 | NR1H2 (0.50) | NR1H2NR1H3AGTR2KLK5KLK7 | |
| SCHEMBL16881322 | 0.88 | NR1H2 (0.46) | NR1H2NR1H3AGTR2KLK5MMP1 | |
| SCHEMBL8239010 | 0.85 | AGTR2 (0.50) | NR1H2NR1H3AGTR2MMP1MMP3 | |
| SCHEMBL22904183 | 0.85 | NR1H2 (0.47) | NR1H2NR1H3KLK5KLK7FKBP1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2807153-B1 | HETEROCYCLIC COMPOUNDS AND METHODS FOR THEIR USE | NOVARTIS AG (CH) | 2020-03-25 | — | — | EP | disclosed |
| US-9708275-B2 | Heterocyclic compounds and methods for their use | NOVARTIS AG (CH) | 2017-07-18 | — | — | US | disclosed |
| US-9708275-B2 | Heterocyclic compounds and methods for their use | NOVARTIS AG (CH) | 2017-07-18 | — | — | US | disclosed |
| US-20160257656-A1 | HETEROCYCLIC COMPOUNDS AND METHODS FOR THEIR USE | SPINIFEX PHARMACEUTICALS PTY LTD (AU) | 2016-09-08 | — | — | US | disclosed |
| US-20160257656-A1 | HETEROCYCLIC COMPOUNDS AND METHODS FOR THEIR USE | SPINIFEX PHARMACEUTICALS PTY LTD (AU) | 2016-09-08 | — | — | US | disclosed |
| US-20150011565-A1 | Heterocyclic Compounds and Methods For Their Use | NOVARTIS AG (CH) | 2015-01-08 | — | — | US | disclosed |
| US-20150011565-A1 | Heterocyclic Compounds and Methods For Their Use | NOVARTIS AG (CH) | 2015-01-08 | — | — | US | disclosed |
| WO-2013110134-A1 | HETEROCYCLIC COMPOUNDS AND METHODS FOR THEIR USE | SPINIFEX PHARMACEUTICALS PTY LTD (AU) | 2013-08-01 | — | — | WO | disclosed |
| US-20110183955-A1 | 2-Aminocarbonyl Substituted Piperazine or Diaza-Cyclic Compounds as Apoptosis Protein Inhibitors (Iap) Modulators | NOVARTIS AG (CH) | 2011-07-28 | — | — | US | disclosed |
| US-20110183955-A1 | 2-Aminocarbonyl Substituted Piperazine or Diaza-Cyclic Compounds as Apoptosis Protein Inhibitors (Iap) Modulators | NOVARTIS AG (CH) | 2011-07-28 | — | — | US | disclosed |
| US-7932255-B2 | Controlling cell proliferation | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932255-B2 | Controlling cell proliferation | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932255-B2 | Controlling cell proliferation | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| EP-1874748-B1 | 2 -AMINOCARBONYL SUBSTITUTED PIPERAZINE OR DIAZA-CYCLIC COMPOUNDS AS APOPTOSIS PROTEIN INHIBITOR (IAP) MODULATORS | NOVARTIS AG (CH) | 2009-08-12 | — | — | EP | disclosed |
| EP-1874748-B1 | 2 -AMINOCARBONYL SUBSTITUTED PIPERAZINE OR DIAZA-CYCLIC COMPOUNDS AS APOPTOSIS PROTEIN INHIBITOR (IAP) MODULATORS | NOVARTIS AG (CH) | 2009-08-12 | — | — | EP | disclosed |
| US-20080207630-A1 | 2-Aminocarbonyl Substituted Piperazine or Diaza-Cyclic Compounds as Apoptosis Protein Inhibitors (Iap) Modulators | ECKL ROBERT | 2008-08-28 | — | — | US | disclosed |
| US-20080207630-A1 | 2-Aminocarbonyl Substituted Piperazine or Diaza-Cyclic Compounds as Apoptosis Protein Inhibitors (Iap) Modulators | ECKL ROBERT | 2008-08-28 | — | — | US | disclosed |
| US-20080207630-A1 | 2-Aminocarbonyl Substituted Piperazine or Diaza-Cyclic Compounds as Apoptosis Protein Inhibitors (Iap) Modulators | ECKL ROBERT | 2008-08-28 | — | — | US | disclosed |
| EP-1874748-A1 | 2 -AMINOCARBONYL SUBSTITUTED PIPERAZINE OR DIAZA-CYCLIC COMPOUNDS AS APOPTOSIS PROTEIN INHIBITOR (IAP) MODULATORS | Novartis AG (CH) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006113376-A1 | 2 -AMINOCARBONYL SUBSTITUTED PIPERAZINE OR DIAZA-CYCLIC COMPOUNDS AS APOPTOSIS PROTEIN INHIBITOR (IAP) MODULATORS | NOVARTIS AG (CH) | 2006-10-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160257656-A1 | HETEROCYCLIC COMPOUNDS AND METHODS FOR THEIR USE | AGTR2, AGTR1, BDKRB2 | NR1H2 1059/4885NR1H3 1582/4885AGTR2 1/4885 |
| US-20150011565-A1 | Heterocyclic Compounds and Methods For Their Use | AGTR2, AGTR1, BDKRB2 | NR1H2 1075/4885NR1H3 1589/4885AGTR2 1/4885 |
| US-20080207630-A1 | 2-Aminocarbonyl Substituted Piperazine or Diaza-Cyclic Compounds as Apoptosis Protein Inhibitors (Iap) Modulators | API5, BCL2, BIRC5 | NR1H2 4430/4885NR1H3 4726/4885AGTR2 403/4885 |
| US-20110183955-A1 | 2-Aminocarbonyl Substituted Piperazine or Diaza-Cyclic Compounds as Apoptosis Protein Inhibitors (Iap) Modulators | API5, BCL2, BIRC5 | NR1H2 4430/4885NR1H3 4726/4885AGTR2 403/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.