Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CASP2 | P42575 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | NAAA | Q02083 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | PCNA | P12004 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24514705 | 0.90 | EPHX2 (0.51) | SMN1; SMN2CASP2EPHX2CNR1FAAH | |
| SCHEMBL26706549 | 0.90 | SMN1; SMN2 (0.49) | SMN1; SMN2CASP2TSHRNAAACNR1 | |
| SCHEMBL27410517 | 0.90 | CASP2 (0.52) | SMN1; SMN2CASP2EPHX2TSHRNAAA | |
| SCHEMBL19369656 | 0.89 | CASP2 (0.43) | SMN1; SMN2CASP2TSHRALDH1A1RECQL | |
| SCHEMBL20470066 | 0.88 | FAAH (0.49) | CASP2TSHRALDH1A1RECQLNAAA | |
| SCHEMBL19477862 | 0.88 | CASP2 (0.58) | CASP2TSHRALDH1A1RECQLNAAA | |
| SCHEMBL14616456 | 0.88 | SMN1; SMN2 (0.57) | SMN1; SMN2EPHX2TSHRALDH1A1RAB9A | |
| SCHEMBL20469919 | 0.87 | CASP2 (0.42) | CASP2TSHRALDH1A1RECQLNAAA | |
| SCHEMBL15082721 | 0.87 | SMN1; SMN2 (0.54) | SMN1; SMN2CASP2EPHX2TSHRALDH1A1 | |
| SCHEMBL15888700 | 0.87 | SMN1; SMN2 (0.54) | SMN1; SMN2CASP2EPHX2TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8916569-B2 | Compounds and methods for inhibiting phosphate transport | ARDELYX, INC. (US) | 2014-12-23 | — | — | US | disclosed |
| US-8916569-B2 | Compounds and methods for inhibiting phosphate transport | ARDELYX, INC. (US) | 2014-12-23 | — | — | US | disclosed |