Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RARB | P10826 | 1/20 | 0.34 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.34 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1377069 | 0.88 | TSHR (0.42) | THRATSHRCYP3A4ALDH1A1EPHX2 | |
| SCHEMBL27111047 | 0.87 | EPHX2 (0.50) | ALDH1A1EPHX2CNR1DNM1MEN1 | |
| SCHEMBL26838508 | 0.85 | TSHR (0.43) | THRATSHRCYP3A4ALDH1A1EPHX2 | |
| SCHEMBL12452054 | 0.84 | TSHR (0.42) | TSHRCYP3A4ALDH1A1EPHX2DNM1 | |
| SCHEMBL22856582 | 0.84 | TSHR (0.42) | TSHRCYP3A4ALDH1A1EPHX2DNM1 | |
| SCHEMBL1373151 | 0.83 | CES2 (0.43) | THRATSHRCYP3A4ALDH1A1EPHX2 | |
| SCHEMBL12848670 | 0.82 | TSHR (0.43) | TSHRCYP3A4ALDH1A1DNM1MEN1 | |
| SCHEMBL1376669 | 0.82 | TSHR (0.43) | TSHRCYP3A4ALDH1A1EPHX2DNM1 | |
| SCHEMBL1373497 | 0.82 | ALDH1A1 (0.39) | THRATSHRALDH1A1EPHX2CNR1 | |
| SCHEMBL1373191 | 0.81 | CES2 (0.46) | THRAALDH1A1EPHX2CNR1DNM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8916569-B2 | Compounds and methods for inhibiting phosphate transport | ARDELYX, INC. (US) | 2014-12-23 | — | — | US | disclosed |
| US-8916569-B2 | Compounds and methods for inhibiting phosphate transport | ARDELYX, INC. (US) | 2014-12-23 | — | — | US | disclosed |