Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | MLYCD | O95822 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.33 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2838599 | 0.90 | ALDH1A1 (0.47) | ALDH1A1HPGDPOLBL3MBTL1MLYCD | |
| SCHEMBL15432939 | 0.87 | CA2 (0.36) | ALDH1A1HPGDPOLBL3MBTL1CA2 | |
| SCHEMBL25589242 | 0.84 | HSD17B10 (0.33) | ALDH1A1HPGDBLMPMP22HSD17B10 | |
| SCHEMBL21738499 | 0.83 | ALDH1A1 (0.50) | ALDH1A1HPGDPOLBL3MBTL1CA2 | |
| SCHEMBL21738502 | 0.83 | ALDH1A1 (0.50) | ALDH1A1HPGDPOLBL3MBTL1CA2 | |
| SCHEMBL21738496 | 0.83 | ALDH1A1 (0.50) | ALDH1A1HPGDPOLBL3MBTL1CA2 | |
| Fumaric Acid SCHEMBL16430879 | 0.80 | HCAR2 (0.43) | ALDH1A1HPGDPOLBL3MBTL1MLYCD | |
| SCHEMBL19002633 | 0.79 | POLB (0.37) | ALDH1A1HPGDPOLBL3MBTL1CA2 | |
| SCHEMBL15432906 | 0.79 | HSD17B10 (0.38) | ALDH1A1HPGDCA2MLYCDBLM | |
| SCHEMBL25715103 | 0.77 | KDM5A (0.39) | ALDH1A1HPGDCA2ZDHHC20ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8916569-B2 | Compounds and methods for inhibiting phosphate transport | ARDELYX, INC. (US) | 2014-12-23 | — | — | US | disclosed |
| US-8916569-B2 | Compounds and methods for inhibiting phosphate transport | ARDELYX, INC. (US) | 2014-12-23 | — | — | US | disclosed |