Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPG | Q9Y5X9 | 3/20 | 0.40 |
| ▸ | LPL | P06858 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.32 |
| ▸ | NLN | Q9BYT8 | 2/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.31 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.31 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.31 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.31 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 2/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14948297 | 0.88 | LIPG (0.44) | LIPGLPLHDAC1NLN | |
| SCHEMBL15114365 | 0.81 | LPL (0.46) | LIPGLPLHDAC1NLN | |
| SCHEMBL16355384 | 0.81 | HDAC1 (0.41) | HDAC1HDAC3HDAC2HDAC6OPRD1 | |
| SCHEMBL15114354 | 0.79 | LPL (0.44) | LIPGLPLHDAC1NLN | |
| SCHEMBL10182686 | 0.78 | USP30 (0.43) | LIPGLPLOPRD1HIF1A | |
| SCHEMBL13070991 | 0.78 | NR1I2 (0.39) | LIPGLPLHDAC1HDAC3HDAC2 | |
| SCHEMBL16358805 | 0.77 | AAK1 (0.44) | LIPGLPLHDAC1GSK3BDYRK1A | |
| SCHEMBL15116616 | 0.75 | AAK1 (0.43) | LIPGLPLGSK3BDYRK1AHIF1A | |
| SCHEMBL12158433 | 0.74 | DGAT1 (0.43) | LIPGLPLHDAC1OPRD1 | |
| SCHEMBL15116600 | 0.74 | AAK1 (0.42) | LIPGLPLHDAC1HDAC3HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9382261-B2 | Substituted quinazolinones as HCV inhibitors | JANSSEN SCIENCES IRELAND UC (IE) | 2016-07-05 | — | — | US | disclosed |
| US-20140378485-A1 | QUINAZOLINONE DERIVATIVES AS HCV INHIBITORS | JANSSEN SCIENCES IRELAND UC (IE) | 2014-12-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140378485-A1 | QUINAZOLINONE DERIVATIVES AS HCV INHIBITORS | EIF2AK2, NQO2, IRF3 | LIPG 3029/4885LPL 3232/4885HDAC1 1199/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.