Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.65 |
| ▸ | LMNA | P02545 | 7/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.65 |
| ▸ | MEN1 | O00255 | 4/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.65 |
| ▸ | MAPT | P10636 | 3/20 | 0.65 |
| ▸ | PGR | P06401 | 5/20 | 0.56 |
| ▸ | AR | P10275 | 4/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.56 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.56 |
| ▸ | ABCB11 | O95342 | 3/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.55 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.54 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11122934 | 0.90 | ALDH1A1 (0.65) | ALDH1A1LMNACYP3A4SMN1; SMN2MEN1 | |
| SCHEMBL13981881 | 0.86 | CYP3A4 (0.66) | ALDH1A1LMNACYP3A4SMN1; SMN2MEN1 | |
| SCHEMBL29882740 | 0.86 | CYP3A4 (0.66) | ALDH1A1LMNACYP3A4SMN1; SMN2MEN1 | |
| SCHEMBL18402585 | 0.86 | CYP3A4 (0.66) | ALDH1A1LMNACYP3A4SMN1; SMN2MEN1 | |
| SCHEMBL369752 | 0.86 | CYP3A4 (0.66) | ALDH1A1LMNACYP3A4SMN1; SMN2MEN1 | |
| SCHEMBL10380434 | 0.83 | ALDH1A1 (0.74) | ALDH1A1LMNACYP3A4SMN1; SMN2MEN1 | |
| SCHEMBL11204626 | 0.80 | ALDH1A1 (0.72) | ALDH1A1LMNACYP3A4SMN1; SMN2MEN1 | |
| SCHEMBL666683 | 0.80 | CYP3A4 (0.58) | ALDH1A1LMNACYP3A4SMN1; SMN2MEN1 | |
| Acetic Acid SCHEMBL29398143 | 0.79 | ALDH1A1 (0.69) | ALDH1A1LMNACYP3A4SMN1; SMN2MEN1 | |
| Desoxycorticosterone Acetate SCHEMBL23468085 | 0.78 | ALDH1A1 (1.00) | ALDH1A1LMNACYP3A4SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932382-B2 | Amide substituted heterocylic compound; anticarcinogen; inducing apoptotic cell death, sensitizing cells to inducers of apoptosis | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2011-04-26 | — | — | US | disclosed |
| US-20090082445-A1 | GOSSYPOL CO-CRYSTALS AND THE USE THEREOF | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2009-03-26 | — | — | US | disclosed |
| WO-2008148473-A2 | METHOD FOR THE PRODUCTION OF 17 ALPHA-ACETOXY-6-METHYLENEPREGN-4-ENE-3,20-DIONE, MEDROXYPROGESTERONE ACETATE, AND MEGESTROL ACETATE | BAYER SCHERING PHARMA AG (DE) | 2008-12-11 | — | — | WO | disclosed |
| US-20080269140-A1 | Conformationally Constrained Smac Mimetics and the Uses Thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2008-10-30 | — | — | US | disclosed |
| EP-0479867-A1 | COMPOSITIONS USEFUL AS CONTRACEPTIVES IN MALES. | COHEN MICHAEL (NL) | 1992-04-15 | — | — | EP | disclosed |
| WO-1991000095-A1 | COMPOSITIONS USEFUL AS CONTRACEPTIVES IN MALES | COHEN MICHAEL (NL) | 1991-01-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080269140-A1 | Conformationally Constrained Smac Mimetics and the Uses Thereof | BID, API5, BIRC3 | ALDH1A1 4625/4885LMNA 144/4885CYP3A4 4804/4885 |
| US-20090082445-A1 | GOSSYPOL CO-CRYSTALS AND THE USE THEREOF | BAX, BCL2, CASP8 | ALDH1A1 4286/4885LMNA 1538/4885CYP3A4 3951/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.