SCHEMBL16358

SCHEMBL16358

[c]1ccnc2ccncc12

nearest known ligand 0.31

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16317 0.83 KDM4A (0.32) SIGMAR1
SCHEMBL8727 0.73 ALDH1A1 (0.41)
SCHEMBL3936581 0.73
SCHEMBL199205 0.72 SIGMAR1 (0.36) SIGMAR1
SCHEMBL451881 0.70
SCHEMBL298809 0.68 SIGMAR1 (0.30) SIGMAR1
SCHEMBL80566 0.68 EGFR (0.47)
SCHEMBL3929427 0.68 FGFR1 (0.30)
SCHEMBL857349 0.68 EGFR (0.32)
SCHEMBL856993 0.67 CCNC (0.35)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2398 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11180497-B2 Cyclic compounds as immunomodulating agents ANGEX PHARMACEUTICAL, INC. (US) 2021-11-23 US claimed
US-20200239464-A1 CYCLIC COMPOUNDS AS IMMUNOMODULATING AGENTS ANGEX PHARMACEUTICAL, INC. 2020-07-30 US claimed
EP-3558969-A1 PYRAZOLE DERIVATIVES AS MALT1 INHIBITORS Janssen Pharmaceutica NV (BE) 2019-10-30 EP claimed
WO-2018119036-A1 PYRAZOLE DERIVATIVES AS MALT1 INHIBITORS JANSSEN BIOTECH, INC. (US) 2018-06-28 WO claimed
US-20180170909-A1 PYRAZOLE DERIVATIVES AS MALT1 INHIBITORS JANSSEN-CILAG (FR) 2018-06-21 US claimed
US-9255182-B2 Data storage medium and method for high density data storage INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 2016-02-09 US claimed
US-8592414-B2 JNK inhibitors for the treatment of endometriosis Merck Serono, S.A. (CH) 2013-11-26 US claimed
WO-2013055910-A1 MODULATORS OF THE GPR119 RECEPTOR AND THE TREATMENT OF DISORDERS RELATED THERETO ARENA PHARMACEUTICALS, INC. (US) 2013-04-18 WO claimed
US-20110086864-A1 N-HYDROXYAMIDE DERIVATIVES AND USE THEREOF MERCK SERONO SA (CH) 2011-04-14 US claimed
US-20110065577-A1 Substituted pyridin-4-yl-methyl sulfonamides as fungicides BASF SE (DE) 2011-03-17 US claimed
US-5559119-A IMMUNOSUPPRESSANTS, ANTIINFLAMMATORY AGENTS, FUNGICIDES AND ANTITUMOR AGENTS AMERICAN HOME PRODUCTS CORPORATION (US) 1996-09-24 US claimed
US-5541191-A Rapamycin amidino carbamates AMERICAN HOME PRODUCTS CORPORATION (US) 1996-07-30 US claimed
US-5541192-A Rapamycin amidino carbamates AMERICAN HOME PRODUCTS CORPORATION (US) 1996-07-30 US claimed
US-5532355-A IMMUNOSUPPRESSANTS FOR ORGAN TRANSPLANTS AMERICAN HOME PRODUCTS CORPORATION (US) 1996-07-02 US claimed
US-5519031-A TREATMENT OF RESTENOSIS, IMMUNOSUPPRESIVE AGENTS, ANTIINFLAMMATORY AGENTS, FUNGICIDES OR ANTITUMOR AGENTS AMERICAN HOME PRODUCTS CORPORATION (US) 1996-05-21 US claimed
US-5508286-A Rapamycin amidino carbamates AMERICAN HOME PRODUCTS CORPORATION (US) 1996-04-16 US claimed
US-5463048-A Immunosuppressive, antiinflammatory, antifungal, antitumor, antiproliferative agents AMERICAN HOME PRODUCTS CORPORATION (US) 1995-10-31 US claimed
US-5434260-A Treating transplantation rejection in mammals AMERICAN HOME PRODUCTS CORPORATION (US) 1995-07-18 US claimed
US-5385908-A Hindered esters of rapamycin AMERICAN HOME PRODUCTS CORPORATION (US) 1995-01-31 US claimed
US-5385909-A Heterocyclic esters of rapamycin AMERICAN HOME PRODUCTS CORPORATION (US) 1995-01-31 US claimed