SCHEMBL16317

SCHEMBL16317

[c]1ccnc2cnccc12

nearest known ligand 0.32

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
KDM4A O75164 1/20 0.32
KDM4B O94953 1/20 0.32
KDM5C P41229 1/20 0.32
KDM4C Q9H3R0 1/20 0.32
KDM5B Q9UGL1 1/20 0.32
KDM3A Q9Y4C1 1/20 0.32
SIGMAR1 Q99720 1/20 0.31
FGFR1 P11362 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16358 0.83 SIGMAR1 (0.31) SIGMAR1
SCHEMBL8727 0.73 ALDH1A1 (0.41)
SCHEMBL3936581 0.73
SCHEMBL199205 0.72 SIGMAR1 (0.36) SIGMAR1
SCHEMBL22121606 0.71 PIK3CA (0.41)
SCHEMBL452262 0.70
SCHEMBL292214 0.68 SIGMAR1 (0.30) SIGMAR1
SCHEMBL277722 0.68 MAPT (0.38)
SCHEMBL855569 0.68 EGFR (0.32) KDM4AKDM4BKDM5CKDM4CKDM5B
SCHEMBL3936851 0.68 FGFR1 (0.33) KDM4AKDM4BKDM5CKDM4CKDM5B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2403 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3558969-A1 PYRAZOLE DERIVATIVES AS MALT1 INHIBITORS Janssen Pharmaceutica NV (BE) 2019-10-30 EP claimed
WO-2018119036-A1 PYRAZOLE DERIVATIVES AS MALT1 INHIBITORS JANSSEN BIOTECH, INC. (US) 2018-06-28 WO claimed
US-20180170909-A1 PYRAZOLE DERIVATIVES AS MALT1 INHIBITORS JANSSEN-CILAG (FR) 2018-06-21 US claimed
EP-2501698-B1 FLUORINATED MONOMERS, OLIGOMERS AND POLYMERS FOR USE IN ORGANIC ELECTRONIC DEVICES NAT RES COUNCIL CANADA (CA) 2018-04-25 EP claimed
US-9255182-B2 Data storage medium and method for high density data storage INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 2016-02-09 US claimed
US-8927684-B2 Fluorinated monomers, oligomers and polymers for use in organic electronic devices NATIONAL RESEARCH COUNCIL OF CANADA (CA) 2015-01-06 US claimed
US-8592414-B2 JNK inhibitors for the treatment of endometriosis Merck Serono, S.A. (CH) 2013-11-26 US claimed
EP-2501698-A1 FLUORINATED MONOMERS, OLIGOMERS AND POLYMERS FOR USE IN ORGANIC ELECTRONIC DEVICES National Research Council of Canada (CA) 2012-09-26 EP claimed
US-20120232237-A1 Fluorinated Monomers, Oligomers and Polymers for Use in Organic Electronic Devices NATIONAL RESEARCH COUNCIL OF CANADA (CA) 2012-09-13 US claimed
WO-2011060526-A1 FLUORINATED MONOMERS, OLIGOMERS AND POLYMERS FOR USE IN ORGANIC ELECTRONIC DEVICES NATIONAL RESEARCH COUNCIL OF CANADA (CA) 2011-05-26 WO claimed
US-5559119-A IMMUNOSUPPRESSANTS, ANTIINFLAMMATORY AGENTS, FUNGICIDES AND ANTITUMOR AGENTS AMERICAN HOME PRODUCTS CORPORATION (US) 1996-09-24 US claimed
US-5541191-A Rapamycin amidino carbamates AMERICAN HOME PRODUCTS CORPORATION (US) 1996-07-30 US claimed
US-5541192-A Rapamycin amidino carbamates AMERICAN HOME PRODUCTS CORPORATION (US) 1996-07-30 US claimed
US-5532355-A IMMUNOSUPPRESSANTS FOR ORGAN TRANSPLANTS AMERICAN HOME PRODUCTS CORPORATION (US) 1996-07-02 US claimed
US-5519031-A TREATMENT OF RESTENOSIS, IMMUNOSUPPRESIVE AGENTS, ANTIINFLAMMATORY AGENTS, FUNGICIDES OR ANTITUMOR AGENTS AMERICAN HOME PRODUCTS CORPORATION (US) 1996-05-21 US claimed
US-5508286-A Rapamycin amidino carbamates AMERICAN HOME PRODUCTS CORPORATION (US) 1996-04-16 US claimed
US-5463048-A Immunosuppressive, antiinflammatory, antifungal, antitumor, antiproliferative agents AMERICAN HOME PRODUCTS CORPORATION (US) 1995-10-31 US claimed
US-5434260-A Treating transplantation rejection in mammals AMERICAN HOME PRODUCTS CORPORATION (US) 1995-07-18 US claimed
US-5385908-A Hindered esters of rapamycin AMERICAN HOME PRODUCTS CORPORATION (US) 1995-01-31 US claimed
US-5385909-A Heterocyclic esters of rapamycin AMERICAN HOME PRODUCTS CORPORATION (US) 1995-01-31 US claimed