Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.41 |
| ▸ | NOS3 | P29474 | 1/20 | 0.40 |
| ▸ | NOS1 | P29475 | 1/20 | 0.40 |
| ▸ | NOS2 | P35228 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 4/20 | 0.39 |
| ▸ | HTR2C | P28335 | 2/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.38 |
| ▸ | HTR1D | P28221 | 2/20 | 0.38 |
| ▸ | HTR1B | P28222 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | QPCT | Q16769 | 1/20 | 0.38 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.38 |
| ▸ | UBE2M | P61081 | 1/20 | 0.37 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16302245 | 0.84 | CHRM2 (0.42) | CHRM2CHRM3OPRM1OPRD1LMNA | |
| SCHEMBL4753533 | 0.75 | CHRM3 (0.58) | CHRM2CHRM3OPRM1OPRD1 | |
| SCHEMBL16357870 | 0.73 | LMNA (0.36) | CHRM2CHRM3LMNAALDH1A1POLB | |
| SCHEMBL850628 | 0.70 | ALDH1A1 (0.46) | LMNACHRNA3ALDH1A1POLB | |
| SCHEMBL26149351 | 0.69 | CCNK (0.42) | CHRM2CHRM3OPRM1OPRD1LMNA | |
| SCHEMBL850267 | 0.68 | LMNA (0.39) | CHRM2CHRM3OPRM1OPRD1LMNA | |
| SCHEMBL7880726 | 0.68 | HTR1D (0.54) | HTR2AHTR1DHTR1B | |
| SCHEMBL31495203 | 0.68 | HTR1D (0.54) | HTR2AHTR1DHTR1B | |
| SCHEMBL29780586 | 0.67 | QDPR (0.56) | NOS3NOS1NOS2 | |
| SCHEMBL849513 | 0.66 | CHRNA1 (0.40) | LMNACHRNA3ALDH1A1POLBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010126030-A1 | SPIROIMIDAZOLONE DERIVATIVE | 中外製薬株式会社 (JP) | 2010-11-04 | — | — | WO | disclosed |