Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.33 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22109261 | 0.71 | GLA (0.33) | ALDH1A1KDM4EMAPTGPR119NPC1 | |
| SCHEMBL30900387 | 0.68 | KDM4E (0.34) | ALDH1A1NR1H2KDM4EMAPTTHRB | |
| SCHEMBL16224559 | 0.68 | USP2 (0.39) | ATMNR1H2KDM4EMAPTTHRB | |
| SCHEMBL2395205 | 0.68 | USP2 (0.39) | ATMNR1H2KDM4EMAPTTHRB | |
| SCHEMBL24918232 | 0.68 | USP2 (0.39) | ATMNR1H2KDM4EMAPTTHRB | |
| SCHEMBL5420095 | 0.66 | HSD17B10 (0.42) | NR1H2KDM4EMAPTTHRBGPR119 | |
| SCHEMBL29115999 | 0.66 | NR1H2 (0.50) | NR1H2GPR119NR1H3 | |
| SCHEMBL642698 | 0.66 | NR1H2 (0.50) | NR1H2GPR119NR1H3 | |
| SCHEMBL18071798 | 0.65 | MAPT (0.40) | ALDH1A1KDM4EMAPTTHRBGPR119 | |
| SCHEMBL22820950 | 0.64 | NPC1 (0.38) | NR1H2GPR119UCHL1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009052288-A1 | SPIRO-CONDENSED 1, 3, 4-THIADIAZOLE DERIVATIVES FOR INHIBITING KSP KINESIN ACTIVITY | SCHERING CORPORATION (US) | 2009-04-23 | — | — | WO | disclosed |