Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17535995 | 0.83 | CHRM2 (0.38) | NPC1USP2SMN1; SMN2HSD17B10NR1H2 | |
| SCHEMBL24918232 | 0.81 | USP2 (0.39) | USP2SMN1; SMN2HSD17B10NR1H2CHRM2 | |
| SCHEMBL16224559 | 0.81 | USP2 (0.39) | USP2SMN1; SMN2HSD17B10NR1H2CHRM2 | |
| SCHEMBL2395205 | 0.81 | USP2 (0.39) | USP2SMN1; SMN2HSD17B10NR1H2CHRM2 | |
| SCHEMBL6745485 | 0.80 | SETD7 (0.38) | USP2SMN1; SMN2HSD17B10NR1H2CHRM2 | |
| SCHEMBL26537645 | 0.80 | SETD7 (0.38) | USP2SMN1; SMN2HSD17B10NR1H2CHRM2 | |
| SCHEMBL24267329 | 0.80 | SETD7 (0.38) | USP2SMN1; SMN2HSD17B10NR1H2CHRM2 | |
| SCHEMBL750363 | 0.78 | PDE4B (0.39) | NPC1NR1H2 | |
| SCHEMBL4561006 | 0.78 | NPC1 (0.36) | NPC1USP2SMN1; SMN2HSD17B10NR1H2 | |
| SCHEMBL22820871 | 0.78 | USP2 (0.36) | NPC1USP2SMN1; SMN2HSD17B10NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020257549-A2 | COMPOUNDS FOR TREATMENT OF PD-L1 DISEASES | CHEMOCENTRYX, INC. (US) | 2020-12-24 | — | — | WO | disclosed |