Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 14/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL763574 | 0.88 | TP53 (0.46) | KIF11SIRT1TP53SMN1; SMN2LMNA | |
| SCHEMBL16359685 | 0.85 | KIF11 (0.41) | KIF11SIRT1TP53SMN1; SMN2LMNA | |
| SCHEMBL16358487 | 0.82 | SIRT1 (0.42) | KIF11SIRT1TP53SMN1; SMN2MAPT | |
| SCHEMBL16299521 | 0.82 | KIF11 (0.48) | KIF11SIRT1TP53SMN1; SMN2MAPT | |
| SCHEMBL8404214 | 0.80 | TP53 (0.46) | KIF11SIRT1TP53SMN1; SMN2LMNA | |
| SCHEMBL11917554 | 0.78 | SIRT1 (0.40) | KIF11SIRT1TP53SMN1; SMN2MAPT | |
| SCHEMBL9965419 | 0.78 | SIRT1 (0.40) | KIF11SIRT1TP53SMN1; SMN2MAPT | |
| SCHEMBL8593808 | 0.78 | TP53 (0.47) | KIF11SIRT1TP53SMN1; SMN2LMNA | |
| SCHEMBL16314578 | 0.78 | SIRT1 (0.45) | KIF11SIRT1TP53SMN1; SMN2LMNA | |
| SCHEMBL9962075 | 0.77 | MAPT (0.48) | KIF11SIRT1TP53SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008127715-A1 | CARBOLINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER AND OTHER DISEASES | PTC THERAPEUTICS, INC. (US) | 2008-10-23 | — | — | WO | disclosed |