Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 15/20 | 0.41 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL763956 | 0.87 | TP53 (0.46) | KIF11MEN1KMT2ALMNAMAPT | |
| SCHEMBL16359684 | 0.85 | KIF11 (0.42) | KIF11SIRT1MEN1KMT2ALMNA | |
| SCHEMBL16359931 | 0.83 | SIRT1 (0.48) | KIF11SIRT1MEN1KMT2ALMNA | |
| SCHEMBL16358487 | 0.81 | SIRT1 (0.42) | KIF11SIRT1MAPTTP53SMN1; SMN2 | |
| SCHEMBL763841 | 0.81 | TP53 (0.45) | KIF11MEN1KMT2ALMNAMAPT | |
| SCHEMBL8404214 | 0.80 | TP53 (0.46) | KIF11SIRT1LMNAMAPTTP53 | |
| SCHEMBL8404053 | 0.80 | TP53 (0.43) | KIF11SIRT1MAPTTP53SMN1; SMN2 | |
| SCHEMBL8404209 | 0.78 | TP53 (0.52) | KIF11LMNAMAPTTP53SMN1; SMN2 | |
| SCHEMBL11912559 | 0.78 | TP53 (0.44) | KIF11SIRT1MEN1KMT2ALMNA | |
| SCHEMBL22510289 | 0.78 | SIRT1 (0.44) | KIF11SIRT1MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008127715-A1 | CARBOLINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER AND OTHER DISEASES | PTC THERAPEUTICS, INC. (US) | 2008-10-23 | — | — | WO | disclosed |