Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 4/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 4/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | KDM7A | Q6ZMT4 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16687345 | 0.84 | HTT (0.68) | HTTMAPK1TDP1L3MBTL1LMNA | |
| SCHEMBL9486597 | 0.82 | HTT (0.87) | HTTMAPK1TDP1L3MBTL1LMNA | |
| SCHEMBL10734179 | 0.81 | SRD5A2 (0.52) | HTTTDP1L3MBTL1LMNAMAPT | |
| SCHEMBL15426073 | 0.80 | HTT (0.63) | HTTMAPK1TDP1L3MBTL1LMNA | |
| SCHEMBL17364506 | 0.80 | HTT (0.75) | HTTMAPK1TDP1L3MBTL1LMNA | |
| SCHEMBL9486241 | 0.79 | HTT (0.86) | HTTMAPK1TDP1L3MBTL1LMNA | |
| SCHEMBL9486082 | 0.78 | HTT (0.60) | HTTMAPK1TDP1L3MBTL1LMNA | |
| SCHEMBL16363114 | 0.78 | HTT (0.60) | HTTMAPK1TDP1L3MBTL1LMNA | |
| SCHEMBL9737497 | 0.74 | ALDH1A1 (0.61) | TDP1LMNAPOLBMAPTGAA | |
| SCHEMBL517975 | 0.74 | ALDH1A1 (0.61) | TDP1LMNAPOLBMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9701654-B2 | Process for preparation of dronedarone by removal of hydroxyl group | SANOFI (FR) | 2017-07-11 | — | — | US | disclosed |
| US-20160075674-A1 | PROCESS FOR PREPARATION OF DRONEDARONE BY REMOVAL OF HYDROXYL GROUP | SANOFI (FR) | 2016-03-17 | — | — | US | disclosed |
| US-9221778-B2 | Process for preparation of dronedarone by removal of hydroxyl group | SANOFI (FR) | 2015-12-29 | — | — | US | disclosed |
| US-20150005515-A1 | PROCESS FOR PREPARATION OF DRONEDARONE BY REMOVAL OF HYDROXYL GROUP | SANOFI (FR) | 2015-01-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160075674-A1 | PROCESS FOR PREPARATION OF DRONEDARONE BY REMOVAL OF HYDROXYL GROUP | CYP2C9, CYP3A43, CYP7A1 | HTT 1941/4885MAPK1 1523/4885TDP1 4013/4885 |
| US-20150005515-A1 | PROCESS FOR PREPARATION OF DRONEDARONE BY REMOVAL OF HYDROXYL GROUP | CYP2C9, DHCR7, CYP3A4 | HTT 1766/4885MAPK1 1415/4885TDP1 4045/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.