Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 5/20 | 0.86 |
| ▸ | LMNA | P02545 | 3/20 | 0.86 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.69 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.69 |
| ▸ | EYA3 | Q99504 | 2/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.59 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17364506 | 0.91 | HTT (0.75) | HTTLMNATDP1MAPK1L3MBTL1 | |
| SCHEMBL9486597 | 0.86 | HTT (0.87) | HTTLMNATDP1MAPK1L3MBTL1 | |
| SCHEMBL8624371 | 0.85 | HTT (0.63) | HTTLMNATDP1MAPK1L3MBTL1 | |
| SCHEMBL5711188 | 0.84 | SLC22A12 (0.73) | HTTLMNATDP1MAPK1L3MBTL1 | |
| SCHEMBL9486692 | 0.84 | HTT (0.61) | HTTLMNATDP1MAPK1L3MBTL1 | |
| SCHEMBL9486589 | 0.82 | HTT (0.60) | HTTLMNATDP1MAPK1L3MBTL1 | |
| SCHEMBL16687345 | 0.82 | HTT (0.68) | HTTLMNATDP1MAPK1L3MBTL1 | |
| SCHEMBL14552023 | 0.81 | HTT (0.70) | HTTLMNATDP1MAPK1L3MBTL1 | |
| SCHEMBL9485913 | 0.81 | HTT (0.58) | HTTLMNATDP1MAPK1L3MBTL1 | |
| SCHEMBL282873 | 0.80 | EYA3 (0.65) | HTTLMNATDP1MAPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9708281-B2 | Process for preparation of dronedarone by the use of dibutylaminopropanol reagent | SANOFI (FR) | 2017-07-18 | — | — | US | disclosed |
| US-9701654-B2 | Process for preparation of dronedarone by removal of hydroxyl group | SANOFI (FR) | 2017-07-11 | — | — | US | disclosed |
| US-9611242-B2 | Process for preparation of dronedarone by N-butylation | SANOFI (FR) | 2017-04-04 | — | — | US | disclosed |
| US-20160075673-A1 | PROCESS FOR PREPARATION OF DRONEDARONE BY THE USE OF DIBUTYLAMINOPROPANOL REAGENT | SANOFI (FR) | 2016-03-17 | — | — | US | disclosed |
| US-20160075674-A1 | PROCESS FOR PREPARATION OF DRONEDARONE BY REMOVAL OF HYDROXYL GROUP | SANOFI (FR) | 2016-03-17 | — | — | US | disclosed |
| US-20160009679-A1 | PROCESS FOR PREPARATION OF DRONEDARONE BY N-BUTYLATION | SANOFI (FR) | 2016-01-14 | — | — | US | disclosed |
| US-9221778-B2 | Process for preparation of dronedarone by removal of hydroxyl group | SANOFI (FR) | 2015-12-29 | — | — | US | disclosed |
| US-9221777-B2 | Process for preparation of dronedarone by the use of dibutylaminopropanol reagent | SANOFI (FR) | 2015-12-29 | — | — | US | disclosed |
| US-9174959-B2 | Process for preparation of dronedarone by N-butylation | SANOFI (FR) | 2015-11-03 | — | — | US | disclosed |
| US-9024046-B2 | Reductive amination process for preparation of dronedarone using amine intermediary compound | SANOFI (FR) | 2015-05-05 | — | — | US | disclosed |
| US-20150005515-A1 | PROCESS FOR PREPARATION OF DRONEDARONE BY REMOVAL OF HYDROXYL GROUP | SANOFI (FR) | 2015-01-01 | — | — | US | disclosed |
| US-20140114081-A1 | PROCESS FOR PREPARATION OF DRONEDARONE BY N-BUTYLATION | SANOFI (FR) | 2014-04-24 | — | — | US | disclosed |
| US-20140018554-A1 | REDUCTIVE AMINATION PROCESS FOR PREPARATION OF DRONEDARONE USING AMINE INTERMEDIARY COMPOUND | SANOFI (FR) | 2014-01-16 | — | — | US | disclosed |
| US-5223510-A | ALKYLAMINOALKYL DERIVATIVES OF BENZOFURAN, BENZOTHIOPHENE, INDOLE AND INDOLIZINE, PROCESS FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM | SANOFI (FR) | 1993-06-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140114081-A1 | PROCESS FOR PREPARATION OF DRONEDARONE BY N-BUTYLATION | CYP3A43, CYP3A4, CYP2D6 | HTT 2817/4885LMNA 172/4885TDP1 3552/4885 |
| US-20160075674-A1 | PROCESS FOR PREPARATION OF DRONEDARONE BY REMOVAL OF HYDROXYL GROUP | CYP2C9, CYP3A43, CYP7A1 | HTT 1941/4885LMNA 991/4885TDP1 4013/4885 |
| US-20160075673-A1 | PROCESS FOR PREPARATION OF DRONEDARONE BY THE USE OF DIBUTYLAMINOPROPANOL REAGENT | DHCR7, CYP3A43, CYP7A1 | HTT 4005/4885LMNA 455/4885TDP1 3966/4885 |
| US-20140018554-A1 | REDUCTIVE AMINATION PROCESS FOR PREPARATION OF DRONEDARONE USING AMINE INTERMEDIARY COMPOUND | CYP2D6, CYP2B6, CYP11B2 | HTT 913/4885LMNA 1155/4885TDP1 3839/4885 |
| US-20160009679-A1 | PROCESS FOR PREPARATION OF DRONEDARONE BY N-BUTYLATION | CYP3A43, CYP3A4, CYP2D6 | HTT 2817/4885LMNA 172/4885TDP1 3552/4885 |
| US-20150005515-A1 | PROCESS FOR PREPARATION OF DRONEDARONE BY REMOVAL OF HYDROXYL GROUP | CYP2C9, DHCR7, CYP3A4 | HTT 1766/4885LMNA 936/4885TDP1 4045/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.