Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | GRK6 | P43250 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 4/20 | 0.40 |
| ▸ | AXL | P30530 | 2/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | PRKACA | P17612 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | ABL2 | P42684 | 1/20 | 0.40 |
| ▸ | FRK | P42685 | 1/20 | 0.40 |
| ▸ | MST1R | Q04912 | 1/20 | 0.40 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.40 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15506038 | 0.89 | GLA (0.43) | LMNAMETAXLPLK4ABL1 | |
| SCHEMBL21383502 | 0.88 | MET (0.43) | METAXLPLK4ABL1NTRK1 | |
| SCHEMBL23749324 | 0.88 | MET (0.41) | LMNATP53GRK6METAXL | |
| SCHEMBL30030602 | 0.88 | MET (0.42) | LMNATP53GRK6METAXL | |
| SCHEMBL721541 | 0.88 | MET (0.50) | LMNATP53METAXLPLK4 | |
| SCHEMBL21385290 | 0.87 | MEN1 (0.45) | TP53METMAPTPOLBMEN1 | |
| SCHEMBL21385115 | 0.86 | CYP1A2 (0.41) | METAXLPLK4ABL1NTRK1 | |
| SCHEMBL22234532 | 0.80 | MET (0.43) | TP53METAXLPLK4ABL1 | |
| SCHEMBL17907416 | 0.80 | TSHR (0.48) | LMNATP53PDE4DMAPTPOLB | |
| SCHEMBL24808464 | 0.79 | MET (0.61) | METAXLPLK4ABL1NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2235001-B1 | PROCESS FOR PREPARING PYRIDINONE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2014-12-24 | — | — | EP | disclosed |