Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSC | P53634 | 16/20 | 0.47 |
| ▸ | CTSK | P43235 | 14/20 | 0.47 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.44 |
| ▸ | CTSS | P25774 | 3/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24982366 | 0.86 | CTSC (0.48) | CTSCCTSKTRPA1CTSSCTSB | |
| SCHEMBL16064851 | 0.85 | CTSC (0.63) | CTSCCTSK | |
| SCHEMBL30738857 | 0.84 | CTSK (0.49) | CTSCCTSKCTSSCTSB | |
| SCHEMBL24981572 | 0.84 | CTSC (0.52) | CTSCCTSK | |
| SCHEMBL16064039 | 0.83 | CTSC (0.63) | CTSCCTSKCTSB | |
| SCHEMBL22046325 | 0.81 | CTSC (0.58) | CTSCCTSKTRPA1CTSSCTSB | |
| SCHEMBL12383142 | 0.81 | CTSC (0.58) | CTSCCTSKTRPA1CTSSCTSB | |
| SCHEMBL24981995 | 0.80 | CTSC (0.59) | CTSCCTSKCTSSCTSB | |
| SCHEMBL24982011 | 0.80 | CTSK (0.46) | CTSCCTSKCTSSCTSB | |
| SCHEMBL16064465 | 0.80 | CTSC (0.63) | CTSCCTSKCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9073869-B2 | Method of using substituted 2-Aza-bicyclo[2.2.2]octane-3-carboxylic acid (benzyl-cyano-methyl)-amides inhibitors of cathepsin C | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-07-07 | — | — | US | disclosed |
| US-20140378504-A1 | METHOD OF USING SUBSTITUTED 2-AZA-BICYCLO[2.2.2]OCTANE-3-CARBOXYLIC ACID (BENZYL-CYANO-METHYL)-AMIDES INHIBITORS OF CATHEPSIN C | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-12-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140378504-A1 | METHOD OF USING SUBSTITUTED 2-AZA-BICYCLO[2.2.2]OCTANE-3-CARBOXYLIC ACID (BENZYL-CYANO-METHYL)-AMIDES INHIBITORS OF CATHEPSIN C | CTSC, CTSZ, CTSB | CTSC 1/4885CTSK 11/4885TRPA1 3799/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.