Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 10/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 7/20 | 0.44 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18997474 | 0.86 | ALDH1A1 (0.51) | ALDH1A1EPHX2EPHX1CXCR3LMNA | |
| SCHEMBL4925631 | 0.81 | EPHX2 (0.69) | ALDH1A1EPHX2EPHX1 | |
| SCHEMBL21133374 | 0.78 | ALDH1A1 (0.46) | ALDH1A1EPHX2EPHX1CXCR3LMNA | |
| SCHEMBL5537790 | 0.78 | ALDH1A1 (0.47) | ALDH1A1EPHX2EPHX1CXCR3DRD2 | |
| SCHEMBL14679328 | 0.77 | CTSK (0.55) | ALDH1A1EPHX1 | |
| SCHEMBL13223508 | 0.76 | CA1 (0.49) | ALDH1A1EPHX2EPHX1 | |
| SCHEMBL29313402 | 0.76 | EPHX2 (0.49) | ALDH1A1EPHX2EPHX1 | |
| SCHEMBL11922672 | 0.76 | ALDH1A1 (0.49) | ALDH1A1EPHX2EPHX1CXCR3 | |
| SCHEMBL19752841 | 0.75 | EPHX2 (0.39) | ALDH1A1EPHX2EPHX1LMNANPSR1 | |
| SCHEMBL19002258 | 0.74 | HSD11B1 (0.50) | ALDH1A1EPHX2EPHX1CXCR3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9242975-B2 | Heterocyclic-substituted pyridyl compounds useful as kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-01-26 | — | — | US | disclosed |
| US-8987311-B2 | Triazolyl-substituted pyridyl compounds useful as kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2015-03-24 | — | — | US | disclosed |
| US-20150045347-A1 | TRIAZOLYL-SUBSTITUTED PYRIDYL COMPOUNDS USEFUL AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2015-02-12 | — | — | US | disclosed |
| US-20150011532-A1 | HETEROCYCLIC-SUBSTITUTED PYRIDYL COMPOUNDS USEFUL AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2015-01-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150045347-A1 | TRIAZOLYL-SUBSTITUTED PYRIDYL COMPOUNDS USEFUL AS KINASE INHIBITORS | IRAK4, IRAK3, IRAK1 | ALDH1A1 3721/4885EPHX2 4222/4885EPHX1 3867/4885 |
| US-20150011532-A1 | HETEROCYCLIC-SUBSTITUTED PYRIDYL COMPOUNDS USEFUL AS KINASE INHIBITORS | IRAK4, IRAK1, IRAK2 | ALDH1A1 4086/4885EPHX2 2755/4885EPHX1 2811/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.