SCHEMBL1636868

SCHEMBL1636868

CCC(C)(C)c1ccc(OC(C)=O)c(C(C)(C)CC)c1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 6/20 0.60
NPSR1 Q6W5P4 5/20 0.60
SMN1; SMN2 Q16637 5/20 0.60
MEN1 O00255 4/20 0.60
KMT2A Q03164 4/20 0.60
ALDH1A1 P00352 3/20 0.60
MAPT P10636 4/20 0.46
HTT P42858 3/20 0.46
UBE2N P61088 2/20 0.46
GLA P06280 1/20 0.46
MITF O75030 1/20 0.46
RAB9A P51151 4/20 0.42
RAD52 P43351 2/20 0.42
STAT3 P40763 1/20 0.42
RCE1 Q9Y256 1/20 0.42
APAF1 O14727 1/20 0.42
HSP90AA1 P07900 1/20 0.42
NOD2 Q9HC29 1/20 0.42
RARG P13631 1/20 0.40
RXRA P19793 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1953482 0.89 MAPK1 (0.62) MAPK1NPSR1SMN1; SMN2MEN1KMT2A
SCHEMBL23095180 0.87 ALDH1A1 (0.49) MAPK1NPSR1SMN1; SMN2MEN1KMT2A
SCHEMBL1508461 0.87 MAPK1 (0.56) MAPK1NPSR1SMN1; SMN2MEN1KMT2A
SCHEMBL8145475 0.86 MAPK1 (0.59) MAPK1NPSR1SMN1; SMN2MEN1KMT2A
SCHEMBL28378699 0.86 MAPK1 (0.59) MAPK1NPSR1SMN1; SMN2MEN1KMT2A
SCHEMBL1636866 0.85 MAPK1 (0.58) MAPK1NPSR1SMN1; SMN2MEN1KMT2A
SCHEMBL5143775 0.84 MAPK1 (0.56) MAPK1NPSR1SMN1; SMN2MEN1KMT2A
SCHEMBL28208150 0.84 MAPK1 (0.56) MAPK1NPSR1SMN1; SMN2MEN1KMT2A
SCHEMBL1508563 0.82 MAPK1 (0.55) MAPK1NPSR1SMN1; SMN2MEN1KMT2A
SCHEMBL2449720 0.82 NPSR1 (0.55) MAPK1NPSR1SMN1; SMN2MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 78 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104530415-B A kind of different functionalization Y types polyethyleneglycol derivative, preparation method and its bio-related substance 厦门赛诺邦格生物科技股份有限公司 2017-09-01 CN claimed
CN-104530417-A Multifunctional H-type polyethylene glycol derivative and preparation method thereof XIAMEN SINOPEG BIOTECH INC 2015-04-22 CN claimed
CN-104530415-A Hetero-functionalized Y-type polyethylene glycol derivative, preparation method and biologically related substance thereof XIAMEN SINOPEG BIOTECH INC 2015-04-22 CN claimed
CN-104109235-A Mono-functionalized polyethylene glycol with nitrogen atom branched center and its preparation method and biologically-relevant matter XIAMEN SINOPEG BIOTECH CO LTD 2014-10-22 CN claimed
WO-2023129564-A9 DEGRADERS OF GRK2 AND USES THEREOF CYGNAL THERAPEUTICS, INC. (US) 2024-02-08 WO disclosed
EP-4277636-A1 MODIFIED OLIGONUCLEOTIDES Alnylam Pharmaceuticals, Inc. (US) 2023-11-22 EP disclosed
WO-2023129564-A1 DEGRADERS OF GRK2 AND USES THEREOF CYGNAL THERAPEUTICS, INC. (US) 2023-07-06 WO disclosed
WO-2023069495-A1 OLIGONUCLEOTIDES WITH 2'-DEOXY-2'-F-2'-C-METHYL NUCLEOTIDES ALNYLAM PHARMACEUTICALS, INC. (US) 2023-04-27 WO disclosed
WO-2022155418-A9 MODIFIED OLIGONUCLEOTIDES ALNYLAM PHARMACEUTICALS, INC. (US) 2023-03-09 WO disclosed
CN-115103907-A Compositions and methods for enhancing immune activity 金橘生物科技公司 2022-09-23 CN disclosed
WO-2022155418-A1 MODIFIED OLIGONUCLEOTIDES ALNYLAM PHARMACEUTICALS, INC. (US) 2022-07-21 WO disclosed
CN-110520117-A Substituted eutectic of glycine compound and application thereof SYNEURX INT TAIWAN CORP 2019-11-29 CN disclosed
WO-2006066598-A2 ANTIBODY BINDING AFFINITY LIGANDS NOVO NORDISK A/S (DK) 2006-06-29 WO disclosed
EP-1640379-A1 METHOD OF SYNTHESIZING SUGAR CHAIN Mitsubishi Chemical Corporation (JP) 2006-03-29 EP disclosed
US-6630496-B1 Antiinflammatory agents inhibit phospholipase 2, affecting both protaglandin and leukotriene production; indoles substituted in 2 position by 2,4-dioxo-thiazol-3-yl methylidene GENETICS INSTITUTE LLC 2003-10-07 US disclosed
CN-1347693-A Novel compounds, their synthesis and therapeutic use GILEAD SCIENCES INC (US) 2002-05-08 CN disclosed
CN-1272105-A Compound containing six-membered rings, processes for their preparation, and their use as medicaments GILEAD SCIENCES INC (US) 2000-11-01 CN disclosed
US-5024923-A Sulfur-containing metal complex FUJI PHOTO FILM CO., LTD. (JP) 1991-06-18 US disclosed
US-4981773-A Method for stabilization of organic base substances against light FUJI PHOTO FILM CO., LTD. (JP) 1991-01-01 US disclosed
US-4929540-A 5-PYRAZOLONE COUPLER WITH NITROGEN-HETEROCYCLE-THIOELIMINATABLE GROUP FUJI PHOTO FILM CO., LTD. (JP) 1990-05-29 US disclosed